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Catecholaminergic function and temperament in major depressive disorder: a negative report.
Hansenne, Michel; Ansseau, Marc
1998In Psychoneuroendocrinology, 23 (5), p. 477-83
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Keywords :
Adolescent; Adrenergic alpha-Agonists/pharmacology; Adult; Apomorphine/diagnostic use; Catecholamines/physiology; Clonidine/diagnostic use; Depressive Disorder/blood/physiopathology/psychology; Dopamine Agonists/diagnostic use; Escape Reaction; Exploratory Behavior; Female; Human Growth Hormone/blood; Humans; Male; Middle Aged; Personality Tests; Psychiatric Status Rating Scales; Reward; Temperament/physiology
Abstract :
[en] In the biosocial model of Cloninger, the three personality dimensions are related to different central neurotransmission systems. In agreement with this model, a recent study (Wiesbeck et al., 1995) showed an association between growth hormone response to apomorphine, an indirect assessment of the dopaminergic system, and novelty seeking score in alcohol-dependent men. In the present study we investigated the same methodology in a sample of major depressive patients. In addition, we assessed the relationship between noradrenergic function and Cloninger's dimensions using the clonidine test, an indirect assessment of the noradrenergic system. Growth hormone responses to apomorphine and clonidine were not associated with novelty seeking, reward dependence or harm avoidance dimension scores. This study therefore does not confirm the results of Wiesbeck et al. (1995), and does not support an association between noradrenergic activity and reward dependence dimension. However, given the complexity of central neurotransmission systems and the limitations of neuroendocrine challenges for the assessment of those processes, this study could not be considered as definitive evidence against the association between personality dimensions and their hypothesized central substrates.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Author, co-author :
Hansenne, Michel  ;  Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Ansseau, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale
Language :
English
Title :
Catecholaminergic function and temperament in major depressive disorder: a negative report.
Publication date :
1998
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Pergamon Press - An Imprint of Elsevier Science, Oxford, United Kingdom
Volume :
23
Issue :
5
Pages :
477-83
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 October 2009

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