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Le potentiel evoque cognitif P300 (II): variabilite interindividuelle et application clinique en psychopathologie.
Hansenne, Michel
2000In Neurophysiologie Clinique, 30 (4), p. 211-31
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Keywords :
Aging; Animals; Event-Related Potentials, P300/physiology; Female; Humans; Individuality; Male; Mental Disorders/diagnosis/physiopathology
Abstract :
[en] The P300 wave is one of the cognitive components of the event-related potential (ERP) that is used to investigate the cognitive processes, and which can be used to study patient populations with a variety of psychiatric disorders. Its clinical utility has been increased by the identification of factors that contribute to the variability in its amplitude and latency. However, its value as a diagnostic index has not been entirely established. It can provide a useful recording of patients' information processing, and indicate the severity of the clinical state and its possible evolution. It can also assist in determining what therapeutic approach to adopt. In the present review, the findings in the literature concerning interindividual variation in the P300 wave are first described; several variables significantly influence the amplitude and latency of this wave, such as age, gender, intelligence and personality. Following this, the relevance of the data in the literature on the clinical applications of P300 in psychopathology is examined, including the studies undertaken to obtain an objective diagnostic index for mental disorders and also those carried out to assess the problems concerning the interpretation of information connected with the mental pathologies examined. P300-associated findings on dementia, schizophrenia, depression, alcoholism, drug addiction, anxiety disorders (panic disorder, obsessive-compulsive disorder, and post-traumatic stress syndrome) and on personality disorders (schizoid, antisocial or borderline personality disorder) have been examined in detail.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Author, co-author :
Hansenne, Michel  ;  Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles
Language :
French
Title :
Le potentiel evoque cognitif P300 (II): variabilite interindividuelle et application clinique en psychopathologie.
Alternative titles :
[en] The p300 cognitive event-related potential. II. Individual variability and clinical application in psychopathology
Publication date :
2000
Journal title :
Neurophysiologie Clinique
ISSN :
0987-7053
eISSN :
1769-7131
Publisher :
Elsevier, Paris, France
Volume :
30
Issue :
4
Pages :
211-31
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 October 2009

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