Serotonergic-1a activity and contingent negative variation.

Hansenne, Michel; Pitchot, William; Pinto, Emmanuel; Papart, Patrick; Ansseau, Marc

doi:10.1016/S0301-0511(99)00047-2

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Serotonergic-1a activity and contingent negative variation.

Hansenne, Michel; Pitchot, William; Pinto, Emmanuel et al.

2000 • In Biological Psychology, 52 (3), p. 259-65

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https://hdl.handle.net/2268/26145

DOI
10.1016/S0301-0511(99)00047-2

PubMed
10725568

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Keywords :

Adult; Depression/physiopathology; Female; Humans; Male; Middle Aged; Piperazines/pharmacology; Receptors, Serotonin/physiology; Reinforcement (Psychology); Serotonin Agonists/pharmacology

Abstract :

[en] While cholinergic, dopaminergic, noradrenergic, and gabaergic effects on contingent negative variation (CNV) have been largely described, little is known about serotonergic influence. Therefore, the relationship between CNV and serotonergic activity as reflected by prolactin (PRL) response to flesinoxan, a 5-HT(1A) full agonist, has been investigated in 28 healthy volunteers. To investigate the clinical implications of the relationship between CNV and serotonergic-1a activity, a group of 43 depressed patients was included in the study. Results among healthy volunteers showed a significant negative relationship between PRL response to flesinoxan and CNV amplitude at Fz, but no relationship for the other electrodes (Cz and Pz). In depressed patients, the relationships were not significant. Overall, this study does not support serotonergic effects on CNV. However, this information is indirect (correlations) and is limited to 5-HT(1A) activity.

Research center :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Hansenne, Michel ; Université de Liège - ULiège > Département des sciences cognitives > Psycho. de la personnalité et des différences individuelles

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Pinto, Emmanuel ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Papart, Patrick ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Ansseau, Marc ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Language :

English

Title :

Serotonergic-1a activity and contingent negative variation.

Publication date :

2000

Journal title :

Biological Psychology

ISSN :

0301-0511

eISSN :

1873-6246

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

Issue :

Pages :

259-65

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 22 October 2009

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