Article (Scientific journals)
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium .
Li, X.; Tjwa, M.; Van Hove, I. et al.
2008In Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 28 (9), p. 1614-20
Peer Reviewed verified by ORBi
 

Files


Full Text
Li X 2008.pdf
Publisher postprint (1.79 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
VEGF-B; angiogenesis; arteriogenesis; collateral growth; cardiac ischemia; limb ischemia
Abstract :
[en] OBJECTIVE: The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear. METHODS AND RESULTS: We studied the role of VEGF-B in various models of pathological angiogenesis using mice lacking VEGF-B (VEGF-B(-/-)) or overexpressing VEGF-B(167). After occlusion of the left coronary artery, VEGF-B deficiency impaired vessel growth in the ischemic myocardium whereas, in wild-type mice, VEGF-B(167) overexpression enhanced revascularization of the infarct and ischemic border zone. By contrast, VEGF-B deficiency did not affect vessel growth in the wounded skin, hypoxic lung, ischemic retina, or ischemic limb. Moreover, VEGF-B(167) overexpression failed to enhance vascular growth in the skin or ischemic limb. CONCLUSIONS: VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. These insights might offer novel therapeutic opportunities
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Li, X.
Tjwa, M.
Van Hove, I.
Enholm, B.
Neven, E.
Paavonen, K.
Jeltsch, M.
Diez Juan, T.
Sievers, R. E.
Chorianopoulos, E.
Wada, H.
Vanwildemeersch, M.
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Springer, M. L.
Von Degenfeld, G.
Dewerchin, M.
Blau, H. M.
Alitalo, K.
Eriksson, U.
Carmeliet, P.
Moons, L.
More authors (12 more) Less
Language :
English
Title :
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium .
Publication date :
September 2008
Journal title :
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
ISSN :
1049-8834
Publisher :
Scientific Publishing Office American Heart Association, Dallas, United States - Texas
Volume :
28
Issue :
9
Pages :
1614-20
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2010

Statistics


Number of views
67 (2 by ULiège)
Number of downloads
515 (0 by ULiège)

Scopus citations®
 
92
Scopus citations®
without self-citations
66
OpenCitations
 
82

Bibliography


Similar publications



Contact ORBi