Article (Scientific journals)
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
Hansenne, Isabelle; Rasier, G.; Pequeux, Christel et al.
2005In Journal of Neuroimmunology, 158 (1-2), p. 67-75
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Keywords :
thymus; oxytocin; vasopressin; receptors; T-cell differentiation; fetal thymic organ cultures
Abstract :
[en] Ontogenesis of oxytocin (OT) and vasopressin (VP) gene expression and function were investigated in murine thymus. OT and VP transcripts were detected in the thymus on embryonic days 13 and 15, respectively. Corresponding messenger RNAs were evidenced in thymic epithelial cells by in situ hybridization with a neurophysin probe. From all OT and VP receptors, only OTR was expressed by all T-cell subsets, while V1bR was found in double positive and single positive CD8 cells. In fetal thymic organ cultures, OTR antagonist d[DTyr(Et)(2), Thr(4)]OVT increased early apoptosis of CD8 cells, while V1bR antagonist (Sanofi SSR 149415) inhibited T-cell differentiation, and favored CD8 T-cell commitment. (C) 2004 Elsevier B.V. All rights reserved.
Disciplines :
Immunology & infectious disease
Neurosciences & behavior
Author, co-author :
Hansenne, Isabelle ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Embryologie
Rasier, G.
Pequeux, Christel  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Brilot, F.
Renard, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > Rééducation de la parole
Breton, C.
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Legros, Jean-Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Martens, H. J.
Language :
English
Title :
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
Publication date :
January 2005
Journal title :
Journal of Neuroimmunology
ISSN :
0165-5728
eISSN :
1872-8421
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
158
Issue :
1-2
Pages :
67-75
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 October 2009

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