Reference : Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the th...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/25868
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network
English
Hansenne, Isabelle [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Embryologie >]
Rasier, G. [> > > >]
Pequeux, Christel mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Brilot, F. [> > > >]
Renard, Cécile [Centre Hospitalier Universitaire de Liège - CHU > > Rééducation de la parole >]
Breton, C. [> > > >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Legros, Jean-Jacques mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
Martens, H. J. [> > > >]
Jan-2005
Journal of Neuroimmunology
Elsevier Science Bv
158
1-2
67-75
Yes (verified by ORBi)
International
0165-5728
Amsterdam
[en] thymus ; oxytocin ; vasopressin ; receptors ; T-cell differentiation ; fetal thymic organ cultures
[en] Ontogenesis of oxytocin (OT) and vasopressin (VP) gene expression and function were investigated in murine thymus. OT and VP transcripts were detected in the thymus on embryonic days 13 and 15, respectively. Corresponding messenger RNAs were evidenced in thymic epithelial cells by in situ hybridization with a neurophysin probe. From all OT and VP receptors, only OTR was expressed by all T-cell subsets, while V1bR was found in double positive and single positive CD8 cells. In fetal thymic organ cultures, OTR antagonist d[DTyr(Et)(2), Thr(4)]OVT increased early apoptosis of CD8 cells, while V1bR antagonist (Sanofi SSR 149415) inhibited T-cell differentiation, and favored CD8 T-cell commitment. (C) 2004 Elsevier B.V. All rights reserved.
http://hdl.handle.net/2268/25868
10.1016/j.jneuroim.2004.08.007

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