Reference : Chapter 1 Variation in Form and Function The Helix-Turn-Helix Regulators of the GntR Sup...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Microbiology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/25857

Title :	Chapter 1 Variation in Form and Function The Helix-Turn-Helix Regulators of the GntR Superfamily
Language :	English
Author, co-author :	Hoskisson, Paul [ > > ]
	Rigali, Sébastien [Université de Liège - ULg > Département des sciences de la vie > Département des sciences de la vie >]
Publication date :	2009
Journal title :	Advances in Applied Microbiology
Publisher :	Academic Press
Volume :	Chapitre 1
Audience :	International
ISSN :	0065-2164
City :	San Diego
Country :	CA
Keywords :	[en] GntR family ; transcriptional regulation
Abstract :	[en] One of the most abundant and widely distributed groups of Helix-turn-helix (HTH) transcription factors is the metabolite-responsive GntR family of regulators (>8500 members in the Pfam database; Jan 2009). These proteins contain a DNA-binding HTH domain at the N terminus of the protein and an effector-binding and/or oligomerisation domain at the C terminus, where upon on binding an effector molecule, a conformational change occurs in the protein which influences the DNA-binding properties of the regulator resulting in repression or activation of transcription. This review summarises what we know about the distribution, structure, function and classification of these regulators and suggests that they may have a future role in biotechnology.
Permalink :	http://hdl.handle.net/2268/25857

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Open access Hoskisson and Rigali 2009.pdf Publisher postprint 403.81 kB View/Open

All documents in ORBi are protected by a user license.

 

© ULg Library Network |  Feedback |  ORBi legal notices

Dspace v1.5