Reference : Chemical and biological investigations of a toxic plant from Central Africa, Magnisti...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
http://hdl.handle.net/2268/25825
Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp montana
English
Karangwa, Charles [Université Nationale du Rwanda - UNR > Pharmacie > > >]
Esters, Virginie mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie > > >]
Frederich, Michel mailto [Université de Liège - ULg > Pharmacie > Pharmacognosie > >]
Tits, Monique mailto [Université de Liège - ULg > Pharmacie > Pharmacognosie > >]
Kadima, Justin N. [Université Nationale du Rwanda - UNR > Pharmacie > > >]
Damas, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Noirfalise, Alfred mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Angenot, Luc mailto [Université de Liège - ULg > Département de pharmacie > Pharmacognosie >]
Feb-2006
Journal of Ethnopharmacology
Elsevier Ireland Ltd
103
3
433-438
Yes (verified by ORBi)
International
0378-8741
1872-7573
Clare
[en] Magnistipula butayei subsp montana ; Chrysobalanaceae ; convulsions ; acute toxicity ; hypothermia ; blood parameters
[en] Magnistipida butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mg/kg) of its aqueous extract, administered orally to adult Wistar rats. This study demonstrated that the freeze-dried aqueous extract (5%, w/w) possesses high toxicity. The extract caused hypothermia, neurological disorders, including extensor reflex of maximal convulsive induced-seizures at about 2h after the administered dose, and death occurred (LD50 = 370 mg/kg) in a dose dependent manner. Blood parameter evaluation revealed slight variations, but these might not have clinical relevance. Histological examination of internal organs (lungs, liver, heart and kidneys) did not reveal any abnormality in the treated group compared to the control. Therefore, it can be concluded that Magnistipida butayei subsp. montana aqueous extract, given orally, is toxic and that its target is the central nervous system. General phytochemical screening revealed that the plant did not contain significant amounts of products known to be toxic, such as alkaloids or cardioactive glycosides, but only catechic tannins, amino acids, saponins and other aphrogen principles in the three parts of the species (fruit, leave and bark). (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Centre Interfacultaire de Recherche du Médicament (C.I.R.M.)
Researchers ; Professionals
http://hdl.handle.net/2268/25825
also: http://hdl.handle.net/2268/30493
10.1016/j.jep.2005.08.019

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