[en] We present the results of a spectroscopic monitoring campaign devoted to three O-type stars in the Carina nebula. We derive the full SB2 orbital solution of the binary system Tr16-112, an exceptional dissymmetrical system consisting of an O5.5-6V((f[SUP]+[/SUP]?p)) primary and a B2V-III secondary. We also report on low-amplitude brightness variations in Tr16-112 that are likely due to the ellipsoidal shape of the O5.5-6 primary revolving in an eccentric orbit around the system's centre of mass. We detect for the first time a clear SB2 binary signature in the spectrum of HD93343 (O8 + O8), although our data are not sufficient to establish an orbital solution. This system also displays low-amplitude photometric modulations. On the other hand, no indication of multiplicity is found in the optical spectra of HD93250. Finally, we discuss the general properties of multiple massive stars in the Carina OB1 association. Based on observations collected at the European Southern Observatory (La Silla, Chile), at Complejo Astronómico El Leoncito (Argentina), at the Cerro Tololo Inter-American Observatory (CTIO) and with XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA). E-mail: email@example.com â ¡ Research Associate FRS/FNRS (Belgium). § Postdoctoral Researcher FRS/FNRS (Belgium). ¶ Senior Research Associate FRS/FNRS (Belgium).