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| Reference : Multiple muscarinic receptor subtypes mediating pulmonary oedema in the rabbit. |
| Scientific journals : Article | |||
| Human health sciences : Pharmacy, pharmacology & toxicology | |||
| http://hdl.handle.net/2268/25585 | |||
| Multiple muscarinic receptor subtypes mediating pulmonary oedema in the rabbit. | |
| English | |
Delaunois, Annie  [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >] | |
| Gustin, Pascal [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >] | |
| Ansay, Michel [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Relations académiques et scientifiques (Méd. vétérinaire) >] | |
| 1994 | |
| Pulmonary Pharmacology | |
| Academic Press | |
| 7 | |
| 3 | |
| 185-93 | |
| Yes (verified by ORBi) | |
| 0952-0600 | |
| London | |
| United Kingdom | |
| [en] Acetylcholine/physiology ; Animals ; Capsaicin ; Female ; Lung/innervation ; Male ; Muscarinic Antagonists/pharmacology ; Nerve Fibers/physiology ; Neuropeptides/secretion ; Pulmonary Edema/chemically induced/physiopathology ; Rabbits ; Receptors, Muscarinic/classification/physiology | |
| [en] The effects of various muscarinic antagonists on acetylcholine (ACh)-induced pulmonary oedema were studied in isolated perfused rabbit lungs. ACh induced a dose-dependent increase in the capillary filtration coefficient (Kf,c). This effect has been previously related to the activation of the capsaicin-sensitive nerve fibres and the release of substance P. Atropine, pirenzepine (M1-selective antagonist) and 4-DAMP (M3-selective antagonist) altered this response, producing a dose-dependent shift to the right of the ACh concentration-Kf,c response curve. By contrast, the M2-selective antagonist AFDX-116 shifted the ACh concentration-response curve to the left. Atropine, pirenzepine and 4-DAMP also significantly reduced the capsaicin-induced increase in the Kf,c, while AFDX-116 enhanced it. We conclude that multiple muscarinic receptor subtypes are present in the rabbit lung, located on the C-fibres, and are involved in the ACh-induced pulmonary oedema. M1 and M3 receptors seem to stimulate the release of neuropeptides from C-fibres, whereas M2 receptors have an inhibitory effect on these fibers. | |
| http://hdl.handle.net/2268/25585 |
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