Article (Scientific journals)
Molecular Layers underlying cytoskeletal remodelling during cortical development
Heng, Julian; Chariot, Alain; Nguyen, Laurent
2010In Trends in Neurosciences, 33, p. 38-47
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Keywords :
Cortex; Cytoskeletton; Cortical development
Abstract :
[en] During neural development, the cytoskeleton of newborn neurons is subjected to extensive and dynamic remodelling to facilitate the sequential steps of neurogenesis, cell migration and terminal differentiation. As we begin to elucidate the molecular mechanisms which precipitate these functions, it is clear that while common factors may be required, different configurations of the cytoskeleton prefigure the correct execution of each step, such that we can define cohorts of proteins whose functions are indispensable for the control of neuronal migration but not terminal differentiation. It has also emerged that these combinatorial protein functions are predetermined by regulated gene expression, as well as precise subcellular localisation of their protein products. We present this view in the context of recent striking data on how the cytoskeleton is regulated during the maturation of cortical neurons within the developing brain.
Research center :
Giga-Neurosciences - ULiège
GIGA Signal Tranduction et GIGA-Neurosciences
Disciplines :
Neurology
Biochemistry, biophysics & molecular biology
Author, co-author :
Heng, Julian
Chariot, Alain ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Language :
English
Title :
Molecular Layers underlying cytoskeletal remodelling during cortical development
Publication date :
2010
Journal title :
Trends in Neurosciences
ISSN :
0166-2236
Publisher :
Elsevier Science, Barking, United Kingdom
Volume :
33
Pages :
38-47
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FNRS, ARC, FBC
Available on ORBi :
since 10 February 2010

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