Article (Scientific journals)
Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease
Louis, Edouard; El Ghoul, Z.; Vermeire, S. et al.
2004In Alimentary Pharmacology and Therapeutics, 19 (5), p. 511-519
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Abstract :
[en] AIM: To test the hypothesis of an association between polymorphism in FCGR3A (the gene coding for FcgammaRIIIa, which is expressed on macrophages and natural killer cells, is involved in antibody-dependent cell-mediated cytotoxicity and has recently been associated with a positive response to rituximab, a recombinant immunoglobulin G1 antibody used in non-Hodgkin's lymphomas) and response to infliximab in Crohn's disease. METHODS: FCGR3A-158 polymorphism was determined using an allele-specific polymerase chain reaction assay in 200 Crohn's disease patients who had received infliximab for either refractory luminal (n = 142) or fistulizing (n = 58) Crohn's disease. Clinical and biological responses (according to C-reactive protein levels) were assessed in 200 and 145 patients, respectively. RESULTS: There were 82.9% clinical responders in V/V patients vs. 72.7% in V/F and F/F patients (N.S.). Globally, the decrease in C-reactive protein was significantly higher in V/V patients than in F carriers (P = 0.0078). A biological response was observed in 100% of V/V patients, compared with 69.8% of F carriers (P = 0.0002; relative risk, 1.43; 95% confidence interval, 1.27-1.61). In the sub-group of patients with elevated C-reactive protein before treatment, the multivariate analysis selected the use of immunosuppressive drugs and FCGR3A genotype as independent factors influencing the clinical response to infliximab (P = 0.003). CONCLUSION: Crohn's disease patients with FCGR3A-158 V/V genotype have a better biological and, possibly, clinical response to infliximab.
Disciplines :
Gastroenterology & hepatology
Pharmacy, pharmacology & toxicology
Author, co-author :
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
El Ghoul, Z.
Vermeire, S.
Dall'Ozzo, S.
Rutgeerts, P.
Paintaud, G.
Belaiche, Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
De Vos, M.
Van Gossum, A.
Colombel, J. F.
Watier, H.
Language :
English
Title :
Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease
Publication date :
01 March 2004
Journal title :
Alimentary Pharmacology and Therapeutics
ISSN :
0269-2813
eISSN :
1365-2036
Publisher :
Blackwell Publishing Ltd, Oxford, United Kingdom
Volume :
19
Issue :
5
Pages :
511-519
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 October 2009

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