Reference : Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal ...
Scientific journals : Article
Social & behavioral sciences, psychology : Sociology & social sciences
Human health sciences : Neurology
Human health sciences : Geriatrics
Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia
Peters, Frederic [Université de Liège - ULG > Centre de Recherches du Cyclotron > > >]
Perani, Daniela [> > > >]
Herholz, Karl [> > > >]
Holthoff, VVjera [> > > >]
Beuthien-Baumann, Bettina [> > > >]
Sorbi, Sandro [> > > >]
Pupi, Alberto [> > > >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Salmon, Eric mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cliniques -Neuroimagerie des troubles de la mémoire et révalid. cogn. > > >]
Dementia & Geriatric Cognitive Disorders
Yes (verified by ORBi)
[en] frontotemporal dementia ; positron emission tomography ; apathy ; disinhibition ; social conduct
[fr] démence ; lobes frontaux ; neuropsychologie
[en] Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex ( 6, 28, - 24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects ( 4, 22, - 22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD. Copyright (C) 2006 S. Karger AG, Basel.
Centre de Recherches du Cyclotron - CRC
EC-FP6: LSHB-CT-2005-512146, FNRS, FMRE, IUAP P5/04

File(s) associated to this reference

Fulltext file(s):

Open access
FINAL-FTDMulticenterStudy_R.docAuthor preprint1.52 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.