ORBi: Peters Frederic - Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia

Reference : Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dem...


	Document type :	Scientific journals : Article
	Discipline(s) :	Social & behavioral sciences, psychology : Sociology & social sciences Human health sciences : Geriatrics Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/2537

Title :	Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia
Language :	English
Author, co-author :	Peters, Frederic [Université de Liège - ULG > Centre de Recherches du Cyclotron > > >]
	Perani, Daniela [> > > >]
	Herholz, Karl [> > > >]
	Holthoff, VVjera [> > > >]
	Beuthien-Baumann, Bettina [> > > >]
	Sorbi, Sandro [> > > >]
	Pupi, Alberto [> > > >]
	Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Collette, Fabienne [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
	Salmon, Eric [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cliniques -Neuroimagerie des troubles de la mémoire et révalid. cogn. > > >]
Publication date :	2006
Journal title :	Dementia & Geriatric Cognitive Disorders
Volume :	21
Issue/season :	5-6
Pages :	373-379
Audience :	International
ISSN :	1420-8008
Keywords :	[en] frontotemporal dementia ; positron emission tomography ; apathy ; disinhibition ; social conduct
	[fr] démence ; lobes frontaux ; neuropsychologie
Abstract :	[en] Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex ( 6, 28, - 24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects ( 4, 22, - 22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD. Copyright (C) 2006 S. Karger AG, Basel.
Research units :	Centre de Recherches du Cyclotron - CRC
Funders :	EC-FP6: LSHB-CT-2005-512146, FNRS, FMRE, IUAP P5/04
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/2537
DOI :	10.1159/000091898
Other URL :	http://content.karger.com/ProdukteDB/produkte.asp?typ=pdf&doi=91898

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Open access	FINAL-FTDMulticenterStudy_R.doc		Author preprint	1.52 MB	View/Open

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