Reference : Effects of various concentrations of glycolic acid at the corneoxenometry and collaxe...
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/2535
Effects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays.
English
Xhauflaire, Emmanuelle [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Claudine [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2008
Journal of Cosmetic Dermatology
Blackwell Publishing
7
3
194-8
Yes (verified by ORBi)
International
1473-2130
1473-2165
[en] BACKGROUND: Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. OBJECTIVE: This study aims to assess the effects of various concentrations of glycolic acid on the stratum corneum and collagen fibers using two selected bioassays. METHODS: Corneoxenometry was performed to test the effects on human stratum corneum. Collaxenometry was similarly designed to quantify the effect on sheets of collagen fibers. Different glycolic acid concentrations ranging from 5% to 70% in alcohol were tested, respectively, for 3- and 10-min exposure times. RESULTS: Both bioassays showed consistent reactivities with a dose-effect relationship when using a 3-min exposure time. By contrast, the tests appeared unreliable or uninformative for the 10-min exposure time. CONCLUSION: Corneoxenometry and collaxenometry appear useful for in vitro testing peeling agents during short exposure times.
http://hdl.handle.net/2268/2535
10.1111/j.1473-2165.2008.00388.x

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