Reference : Biometrology of physical properties of skin in thyroid dysfunction.
Scientific journals : Article
Human health sciences : Dermatology
http://hdl.handle.net/2268/2523
Biometrology of physical properties of skin in thyroid dysfunction.
English
Szepetiuk, Grégory [Université de Liège - ULg > > Dermatopathologie >]
Pierard, Gérald mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Betea, Daniela mailto [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
Petrossians, Patrick mailto [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
Xhauflaire, Emmanuelle [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
Beckers, Albert mailto [Université de Liège - ULg > Département des sciences cliniques > Endocrinologie >]
Quatresooz, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Dermatopathologie >]
2008
Journal of the European Academy of Dermatology & Venereology
Blackwell Publishing
22
10
1173-1177
Yes (verified by ORBi)
International
0926-9959
1468-3083
Oxford
United Kingdom
[en] Adult ; Aged ; Biometry ; Case-Control Studies ; Female ; hydration ; hyperthyroidism ; stratum corneum ; thyroid-stimulating hormone
[en] OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in the presence of moderate thyroid dysfunction. SETTING: University Hospital. PATIENTS AND METHODS: A total of 119 adults suffering from hypothyroidism or hyperthyroidism and 60 healthy controls were enrolled in this study. Hormonal dosages (TSH, fT3, fT4) were assessed in the serum. A series of biometrological assessments were also performed on the volar and dorsal aspects of the forearms. These included electrometric assessments (Nova Dermal Phase Meter, Corneometer), evaporimetry (Tewameter)), colorimetry (Mexameter), ultrasound shear wave propagation (Reviscometer) and squamometry X. Correlations were searched between each of the serum hormonal dosages and each of the biometrological parameters. RESULTS: The hormonal changes in the untreated patients with thyroid dysfunction were modest in intensity. A few outlier values with regard to the normal range were found for each biometrological parameter. No correlations were found between fT3 or fT4 and each of the physical parameters. By contrast, significant negative linear correlations were found between thyroid-stimulating hormone (TSH) and skin hydration measured by the Corneometer and the Nova DPM. CONCLUSION: This multipronged exploratory study shows that direct or indirect effects of TSH may influence the stratum corneum hydration. This correlation seemed very sensitive, as no other specific biophysical parameter was significantly correlated with the thyroid hormonal concentrations in the serum. However, our findings do not exclude the possibility of some other skin changes supervening in case of more severe thyroid dysfunction. The mechanism by which TSH alters the stratum corneum hydration is yet unknown.
Researchers ; Professionals
http://hdl.handle.net/2268/2523
also: http://hdl.handle.net/2268/70404
10.1111/j.1468-3083.2008.02738.x

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