Article (Scientific journals)
Biometrology of physical properties of skin in thyroid dysfunction.
Szepetiuk, Grégory; Pierard, Gérald; Betea, Daniela et al.
2008In Journal of the European Academy of Dermatology and Venereology, 22 (10), p. 1173-1177
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Keywords :
Adult; Aged; Biometry; Case-Control Studies; Female; hydration; hyperthyroidism; stratum corneum; thyroid-stimulating hormone
Abstract :
[en] OBJECTIVE: There is ample clinical evidence that skin is responsive to physiopathological levels of circulating thyroid hormones. The aim of the study was to assess some physical changes of the skin in the presence of moderate thyroid dysfunction. SETTING: University Hospital. PATIENTS AND METHODS: A total of 119 adults suffering from hypothyroidism or hyperthyroidism and 60 healthy controls were enrolled in this study. Hormonal dosages (TSH, fT3, fT4) were assessed in the serum. A series of biometrological assessments were also performed on the volar and dorsal aspects of the forearms. These included electrometric assessments (Nova Dermal Phase Meter, Corneometer), evaporimetry (Tewameter)), colorimetry (Mexameter), ultrasound shear wave propagation (Reviscometer) and squamometry X. Correlations were searched between each of the serum hormonal dosages and each of the biometrological parameters. RESULTS: The hormonal changes in the untreated patients with thyroid dysfunction were modest in intensity. A few outlier values with regard to the normal range were found for each biometrological parameter. No correlations were found between fT3 or fT4 and each of the physical parameters. By contrast, significant negative linear correlations were found between thyroid-stimulating hormone (TSH) and skin hydration measured by the Corneometer and the Nova DPM. CONCLUSION: This multipronged exploratory study shows that direct or indirect effects of TSH may influence the stratum corneum hydration. This correlation seemed very sensitive, as no other specific biophysical parameter was significantly correlated with the thyroid hormonal concentrations in the serum. However, our findings do not exclude the possibility of some other skin changes supervening in case of more severe thyroid dysfunction. The mechanism by which TSH alters the stratum corneum hydration is yet unknown.
Disciplines :
Dermatology
Author, co-author :
Szepetiuk, Grégory ;  Université de Liège - ULiège > Dermatopathologie
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Betea, Daniela ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Petrossians, Patrick  ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Xhauflaire, Emmanuelle ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Quatresooz, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Biometrology of physical properties of skin in thyroid dysfunction.
Publication date :
2008
Journal title :
Journal of the European Academy of Dermatology and Venereology
ISSN :
0926-9959
eISSN :
1468-3083
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
22
Issue :
10
Pages :
1173-1177
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 December 2008

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