Article (Scientific journals)
Nouvelles strategies dans la prise en charge de l'allo-immunisation foeto-maternelle anti-RHD (Rhesus)
Minon, J. M.; Gerard, Christiane; Dricot, J. F. et al.
2006In Revue Médicale de Liège, 61 (11), p. 756-62
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Keywords :
fetal hemolytic disease; Prenatal diagnosis; Fetal RHD genotype; Fetal Doppler
Abstract :
[en] Despite generalisation of anti-D immunoprophylaxis, RhD allo-immunisation still remains the major cause of severe haemolytic disease of the fetus and of the newborn (HDFN). The routine follow up of pregnant women comprises: the ABO/D, Rh/Kell red cells typing and the search for irregular antibodies. In case of anti-D immunisation, the paternal Rh phenotype, when known, provides useful information regarding the probability for the fetus to have inherited the D antigen and thereby to be exposed to the risk of HDFN. The antibody titre, which is predictive of possible in vivo haemolysis, must be interpreted in the light of the previous obstetric history, and can lead to the decision of invasive amniocentesis. Then the measurement of the optical density (deltaOD450 nm) and the fetal RhD typing can be realised on amniotic fluid. New molecular techniques make it possible now to demonstrate the presence of fetal DNA in maternal plasma. These methods lying on non invasive procedures could advantageously be applied to the genotyping of fetal RHD during pregnancy. The present paper aims to discuss the predictive values of RHD fetal genotype in maternal plasma of RhD negative mothers. The ante-partum management of immunised pregnant women is reviewed in the light of this new molecular approach combined to Doppler ultrasonography of the fetal middle cerebral artery. This non invasive method for determining fetal RHD genotype could be systematically proposed to all RhD negative pregnant women for a better targeted prenatal follow-up and an increased efficacy of RhD prophylaxis.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Minon, J. M.
Gerard, Christiane ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Dricot, J. F.
Neve, C.
Senterre, J. M.
Schaaps, Jean-Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Embryologie
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
French
Title :
Nouvelles strategies dans la prise en charge de l'allo-immunisation foeto-maternelle anti-RHD (Rhesus)
Alternative titles :
[en] New Approaches to Prenatal Diagnosis of Rhesus Incompatibility
Publication date :
November 2006
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Hopital de Baviere, Liège, Belgium
Volume :
61
Issue :
11
Pages :
756-62
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 March 2010

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