Reference : Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Phytobiology (plant sciences, forestry, mycology...)
http://hdl.handle.net/2268/24994
Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs
English
Brouta, Frédéric [> > > >]
Descamps, Frédéric [> > > >]
Vermout, Sandy [> > > >]
Monod, Michel [> > > >]
Losson, Bertrand mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires >]
Mignon, Bernard mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Parasitologie et pathologie des maladies parasitaires >]
Dec-2003
Medical Mycology
Taylor & Francis Ltd
41
6
495-501
Yes (verified by ORBi)
International
1369-3786
Abingdon
[en] immune response ; keratinase ; metalloprotease ; Microsporum canis
[en] In order to better understand the host-fungus relationship in Microsporum canis dermatophytosis and to identify major fungal antigens, the immune response to a crude exoantigen preparation and to a purified recombinant keratinolytic metalloprotease (r-MEP3) was evaluated in guinea pigs experimentally infected with M. canis. Humoral and cellular immune responses were assessed from day 0 to day 57 post-infection (PI), the former by enzyme-linked immunosorbent assay (ELISA) and the latter via a lymphocyte proliferation assay. Infected guinea pigs developed humoral and cellular responses to both M. canis exoantigen and r-MEP3, while no specific immune response to these antigens was observed in control animals. This is the first report on the development of both humoral and cell-mediated immune responses to a purified keratinase in M. canis dermatophytosis.
http://hdl.handle.net/2268/24994

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