Reference : Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/24974
Regulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases.
English
Gloire, Geoffrey mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
Charlier, Edith mailto [Université de Liège - ULg > > GIGA-R : Virologie - Immunologie >]
Piette, Jacques mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - GIGA-Research >]
2008
Biochemical Pharmacology
Elsevier Science
Yes (verified by ORBi)
International
0006-2952
Oxford
United Kingdom
[en] Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade that culminates in cellular apoptosis. Despite the CD95 receptor does not exhibit any kinase activity by itself, phosphorylation/dephosphorylation events seem important to regulate many aspects of CD95-mediated apoptosis. Here, we try to highlight particularly the importance of protein phosphatases in the modulation of the CD95 system.
http://hdl.handle.net/2268/24974

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