Article (Scientific journals)
Prevention of hip fractures in osteoporosis
Neuprez, Audrey; Hiligsmann, Mickaël; Bruyère, Olivier et al.
2007In Minerva Ortopedica e Traumatologica, 58 (5), p. 423-437
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Keywords :
Osteoporosis; Hip fracture; Prevention; Treatment; Bisphosphonates; Strontium ranelate
Abstract :
[en] Hip fracture is the major clinical consequence of osteoporosis. It is linked with decreased life expectancy and quality of life, placing an ever increasing burden on health services. Few medications have unequivocally demonstrated their ability to reduce hip fracture risk in osteoporotic subjects. Daily alendronate and risedronate reduce hip fracture in patients with low bone mineral density and prevalent vertebral fractures. Intravenous bisphosphonates have been developed, in response to long-term poor adherence to oral anti-osteoporotic treatments. Once-yearly zoledronic acid reduces fracture rates at the spine, non-spine and hip locations. Strontium ranelate, the first drug to uncouple bone formation from bone resorption has also demonstrated its ability to reduce hip fractures in patients above 74 years old, with prevalent low bone mineral density. Calcium and vitamin D supplementation are prerequisite for the management of elderly subjects and should always been associated to anti-resorptive or bone forming agents. Non-pharmacological management of osteoporosis is recommended cannot be considered a substitute for pharmacological treatment of osteoporosis, not even in old age.
Disciplines :
Rheumatology
Author, co-author :
Neuprez, Audrey ;  Université de Liège - ULiège > 4e doct. médecine
Hiligsmann, Mickaël ;  Université de Liège - ULiège > HEC-Ecole de gestion : UER > Economie industrielle
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique - Département des sciences de la santé publique
Ethgen, Olivier ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique : aspects spécifiques
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
Prevention of hip fractures in osteoporosis
Publication date :
2007
Journal title :
Minerva Ortopedica e Traumatologica
ISSN :
0394-3410
eISSN :
1827-1707
Publisher :
Pubblicazione Periodica Mensile
Volume :
58
Issue :
5
Pages :
423-437
Peer reviewed :
Peer reviewed
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