Reference : NEMA NU4-2008 Image Quality Performance Report for the microPET Focus 120 and for Variou...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Physics
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/24795
NEMA NU4-2008 Image Quality Performance Report for the microPET Focus 120 and for Various Transmission and Reconstruction Methods
English
Bahri, Mohamed Ali mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Warnock, Geoffrey [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Seret, Alain mailto [Université de Liège - ULg > Département de physique > Imagerie médicale expérimentale >]
Oct-2009
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Society of Nuclear Medicine
50
1730-1738
Yes (verified by ORBi)
International
0161-5505
1535-5667
Reston
VA
[en] microPET ; small-animal PET scanner ; image quality performance ; image reconstruction methods
[en] This work aimed to evaluate the image quality and accuracy of attenuation and scatter corrections provided with the microPET Focus 120 scanner using the National Electrical Manufacturers Association NU4-2008 image quality phantom. Methods: Attenuation correction was obtained from transmission measurements using either a 68Ge or a 57Copoint source. Fully correctedemission images were reconstructed using Fourier rebinning (FORE) and filtered backprojection (FBP). For attenuation data obtained with the 57Co source, fully corrected emission images were also reconstructed using FORE and 2-dimensional (2D) ordered-subset expectation maximization (OSEM), 3-dimensional (3D) filtered backprojection (3DRP), 3D OSEM, and 3D maximum a posteriori methods. The mean activity, the coefficients of variation (COVs) of the uniform slices, the recovery coefficients (RCs) for hot rods, and the spillover ratio (SOR) for nonemittingwater and air compartments were measured. Results: For 57Co-based attenuation correction, the mean activity value differed by less than 3% from the true activity.Measuring the attenuation with 68Ge resulted in lower reconstructed activity and higher COV. On the basis of 57Co measurements, the SORs for air and water nonemitting compartments were the closest to zero for attenuation correction. The RC measured on emission images corrected for attenuation but not for scatter did not show any significant difference linked to the transmissionmethod. However, higherRCswere noted for transmission measurement with 68Ge in coincidence with windowing when emission data were corrected for attenuation and scatter. This resulted from a lower mean value in the uniform area. 2D and 3DRP reconstructionmethods showed little effect on themean activity value, whereas iterative 3D methods gave 7%higher values. Higher RCs were found with iterative reconstruction than with FBP and 3DRP. However, the SOR seemed to be optimal with FBP. SORs were higher with iterative methods and decreased with the number of iterations. Conclusion: For studies of small rodents with the Focus 120, 57Co transmission seems to be the most suitable method for attenuation correction. FORE and 2D reconstruction methods appear to be a good compromise between overall image quality and reconstruction time: OSEM provides the largest contrasts, but FBP provides superior attenuation and scatter correction.
Centre de Recherches du Cyclotron - CRC
FRS-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/24795
10.2967/jnumed.109.063974

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Manuscript_Bahri_JNM_Rev2.pdfAn article published in the Journal of Nuclear Medicine (JNM) is free and open to the public six months after its publication: http://jnm.snmjournals.org/ Author postprint2.04 MBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.