ORBi: Schoenen Jean - Contingent negative variation and efficacy of beta-blocking agents in migraine

Reference : Contingent negative variation and efficacy of beta-blocking agents in migraine


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/24649

Title :	Contingent negative variation and efficacy of beta-blocking agents in migraine
Language :	English
Author, co-author :	Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
	MAERTENS DE NOORDHOUT, Alain [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR]
	Timsit-Berthier, Martine [> > > >]
	Timsit, M. [> > > >]
Publication date :	1986
Journal title :	Cephalalgia : An International Journal of Headache
Publisher :	Blackwell Science
Volume :	6
Issue/season :	4
Pages :	229-33
Audience :	International
ISSN :	0333-1024
e-ISSN :	1468-2982
City :	Osney Mead Oxford
Country :	United Kingdom
Keywords :	[en] Adrenergic beta-Antagonists/pharmacology/therapeutic use ; Adult ; Contingent Negative Variation/drug effects ; Electrophysiology/drug effects ; Female ; Humans ; Male ; Metoprolol/pharmacology/therapeutic use ; Migraine Disorders/prevention & control ; Propranolol/pharmacology/therapeutic use
Abstract :	[en] Thirty-three patients with common migraine underwent contingent negative variation (CNV) recordings before receiving prophylactic beta-blocker treatment with either metoprolol (27 patients) or propranolol (6 patients) at mean daily dosages of 110 mg and 122 mg, respectively. After 3 months the therapeutic efficacy of the beta-blocker was assessed in each patient by means of a global severity score and compared with the initial CNV recordings. The mean clinical improvement was 62%. A significant positive correlation was found between CNV amplitude before prophylaxis and the clinical response to beta-blockers: patients with higher CNV tended to respond better to therapy. Eight of 10 patients with a CNV amplitude higher than -25 microV had a more than 50% reduction of the severity score--that is, a good or excellent response to the beta-blocking agent--whereas only 2 of 9 patients with an amplitude lower than -20 microV had a good response.
Permalink :	http://hdl.handle.net/2268/24649

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