Article (Scientific journals)
Contingent negative variation and efficacy of beta-blocking agents in migraine
Schoenen, Jean; MAERTENS DE NOORDHOUT, Alain; Timsit-Berthier, Martine et al.
1986In Cephalalgia, 6 (4), p. 229-33
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Keywords :
Adrenergic beta-Antagonists/pharmacology/therapeutic use; Adult; Contingent Negative Variation/drug effects; Electrophysiology/drug effects; Female; Humans; Male; Metoprolol/pharmacology/therapeutic use; Migraine Disorders/prevention & control; Propranolol/pharmacology/therapeutic use
Abstract :
[en] Thirty-three patients with common migraine underwent contingent negative variation (CNV) recordings before receiving prophylactic beta-blocker treatment with either metoprolol (27 patients) or propranolol (6 patients) at mean daily dosages of 110 mg and 122 mg, respectively. After 3 months the therapeutic efficacy of the beta-blocker was assessed in each patient by means of a global severity score and compared with the initial CNV recordings. The mean clinical improvement was 62%. A significant positive correlation was found between CNV amplitude before prophylaxis and the clinical response to beta-blockers: patients with higher CNV tended to respond better to therapy. Eight of 10 patients with a CNV amplitude higher than -25 microV had a more than 50% reduction of the severity score--that is, a good or excellent response to the beta-blocking agent--whereas only 2 of 9 patients with an amplitude lower than -20 microV had a good response.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
MAERTENS DE NOORDHOUT, Alain  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Timsit-Berthier, Martine ;  Université de Liège - ULiège
Timsit, Meyer ;  Université de Liège - ULiège
Language :
English
Title :
Contingent negative variation and efficacy of beta-blocking agents in migraine
Publication date :
1986
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science, Osney Mead Oxford, United Kingdom
Volume :
6
Issue :
4
Pages :
229-33
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 September 2009

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