Reference : Self-Treatment of Acute Migraine with Subcutaneous Sumatriptan Using an Auto-Injector De...
Scientific journals : Article
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/24586
Self-Treatment of Acute Migraine with Subcutaneous Sumatriptan Using an Auto-Injector Device: Comparison with Customary Treatment in an Open, Longitudinal Study
English
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Bulcke, J. [> > > >]
Caekebeke, Jo [> > > >]
Dehaene, I. [> > > >]
De Keyser, J. [> > > >]
Hildebrand, G. [> > > >]
Joffroy, A. [> > > >]
Laloux, P. [> > > >]
Louis, P. [> >]
Monseu, G. [> > > >]
Pierre, P. [> >]
Vanderlinden, C. [> >]
Sautois, D. [> >]
Vanderberghe, A. [> >]
Feb-1994
Cephalalgia : An International Journal of Headache
Blackwell Science
14
1
55-63
Yes (verified by ORBi)
International
0333-1024
[en] In a multicenter open longitudinal clinical trial where 479 patients suffering from migraine with or without aura were recruited, patients treated at home one to three migraine attacks with their customary treatment, and subsequently, over a 3-month period, one to three migraine attacks with 6 mg sumatriptan sc using an autoinjector. The headache response to customary treatment was 19% at 1 h and 30.5% at 2 h, and was not significantly different when only attacks treated "adequately" according to accepted treatment recommendations were considered: 16% at 1 h and 35% at 2 h. In contrast, 69% and 82% of patients treated with 6 mg sumatriptan sc had mild headache or no headache at 1 and 2 h respectively, regardless of migraine type or duration of symptoms prior to treatment. Other migraine symptoms (nausea, vomiting, photo- and phonophobia) were effectively treated with sumatriptan. Recurrence of migraine was observed in 31% of patients and was well controlled by a second injection of sumatriptan. It is concluded that 6 mg sumatriptan sc, self-administered using an autoinjector, is well tolerated and more effective than most currently used acute treatments for migraine in a population of severely affected patients consulting a neurologist.
http://hdl.handle.net/2268/24586

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