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Intensity Dependence of Auditory Evoked Potentials Is Pronounced in Migraine: An Indication of Cortical Potentiation and Low Serotonergic Neurotransmission?
Wang, W.; Timsit-Berthier, M.; Schoenen, Jean
1996In Neurology, 46 (5), p. 1404-9
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Keywords :
Adult; Cerebral Cortex/physiology/physiopathology; Electroencephalography; Evoked Potentials, Auditory; Female; Humans; Long-Term Potentiation; Male; Migraine Disorders/physiopathology; Random Allocation; Reference Values; Serotonin/physiology
Abstract :
[en] Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy volunteers. Binaural tones were delivered at 40, 50, 60, and 70 dB sensation level (SL) in a pseudorandomized order. The intensity dependence of the auditory N1-P2 component was significantly greater in MO (p = 0.003) and MA (p = 0.02) patients than in healthy controls, resulting in a much steeper amplitude/stimulus intensity function slope. When three sequential blocks of 40 averaged responses were analyzed at the 40- and 70-dB SL intensities, N1-P2 amplitude decreased in second and third blocks at both intensities in controls, but increased in migraineurs, a difference that was significant in both blocks for the 70-dB SL stimulus. The strong interictal dependence of AEPs on stimulus intensity may thus be due to potentiation (instead of habituation) of the response during repetition of the high-intensity stimulation. In concordance with previous studies of visual evoked potentials, these results confirm that migraine is characterized between attacks by an abnormality of cortical information processing, which might be a consequence of low 5-HT transmission and favor cortical energy demands.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Wang, W.
Timsit-Berthier, M.
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Intensity Dependence of Auditory Evoked Potentials Is Pronounced in Migraine: An Indication of Cortical Potentiation and Low Serotonergic Neurotransmission?
Publication date :
May 1996
Journal title :
Neurology
ISSN :
0028-3878
eISSN :
1526-632X
Publisher :
Lippincott Williams & Wilkins, United States - Maryland
Volume :
46
Issue :
5
Pages :
1404-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 September 2009

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