ORBi: Daubioul C. A. - ffects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis : results of a pilot study

Reference : ffects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic st...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/24506

Title :	ffects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis : results of a pilot study
Language :	English
Author, co-author :	Daubioul, C. A. [ > > ]
	Horsmans, Y. [ > > ]
	Lambert, Philippe [Université de Liège - ULg > Institut des sciences humaines et sociales > Méthodes quantitatives en sciences sociales >]
	Danse, E. [ > > ]
	Delzenne, N. M. [ > > ]
Publication date :	2005
Journal title :	European Journal of Clinical Nutrition
Publisher :	Nature Publishing Group
Volume :	59
Pages :	723-726
Audience :	International
ISSN :	0954-3007
City :	London
Country :	United Kingdom
Keywords :	[en] Nonalcoholic steatohepatitis ; fructans ; triacylglycerol ; blood glucose ; aminotransferases
Abstract :	[en] Objective: In experimental animals, recent results suggest that the addition of inulin-type fructans such as oligofructose (OFS) in the diet decreases triacylglycerol accumulation in the liver tissue. Therefore, we have investigated the effect of daily ingestion of OFS in seven patients with nonalcoholic steatohepatitis (NASH), confirmed by liver biopsies. Design: They received 16 g/day OFS or maltodextrine (placebo) for 8 weeks in a randomized double-blind crossover design. Energy intake, body composition, liver steatosis and blood parameters were analysed after 4 and 8 weeks of dietary supplementation. Results: Compared to placebo, OFS decreased significantly serum aminotransferases, aspartate aminotransferase after 8 weeks, and insulin level after 4 weeks, but this could not be related to significant effect on plasma lipids. Conclusion: This pilot study supports the putative interest of OFS in the management of liver diseases associated with abnormal lipid accumulation in humans.
Permalink :	http://hdl.handle.net/2268/24506
DOI :	10.1038/sj.ejcn.1602127
Other URL :	http://www.nature.com/ejcn/journal/v59/n5/abs/1602127a.html

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