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Zolmitriptan (Zomig, 311c90), a Novel Dual Central and Peripheral 5ht1b/1d Agonist: An Overview of Efficacy
Schoenen, Jean; Sawyer, J.
1997In Cephalalgia, 17 (Suppl 18), p. 28-40
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Abstract :
[en] The efficacy of zolmitriptan (Zomig, 311C90), a 5-hydroxytryptamine (5HT)1B/1D receptor agonist, in the acute oral treatment of migraine was evaluated in an extensive clinical trial program. Four randomized, placebo-controlled studies (total 2480 patients) were performed; data from two of these trials established that a 2.5 mg dose was on the shoulder of the dose-response curve (2-h headache response rate 64%), showing similar efficacy to the 5 mg dose (67%). In this program, the efficacy of zolmitriptan was not influenced by the pretreatment headache duration; the presence of aura preceding the headache, migraine associated with menses or migraine upon awakening; or by concomitant use of oral contraceptives or antidepressants. In addition, zolmitriptan 5 mg proved consistently effective in the treatment of multiple migraine attacks for up to 1 year. Zolmitriptan reduced the incidence of nausea, photophobia and phonophobia, reduced impairment of normal activity and demonstrated positive effects on patients' quality of life. Thus, zolmitriptan is a highly effective acute oral antimigraine therapy, with 2.5 mg providing the optimal balance between efficacy and tolerability.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Sawyer, J.
Language :
English
Title :
Zolmitriptan (Zomig, 311c90), a Novel Dual Central and Peripheral 5ht1b/1d Agonist: An Overview of Efficacy
Publication date :
October 1997
Journal title :
Cephalalgia
ISSN :
0333-1024
eISSN :
1468-2982
Publisher :
Blackwell Science
Volume :
17
Issue :
Suppl 18
Pages :
28-40
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 September 2009

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