Article (Scientific journals)
Interictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Afra, Judit; Mascia, Adolores; GERARD, Pascale et al.
1998In Annals of Neurology, 44 (2), p. 209-15
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Keywords :
Adult; Differential Threshold; Electromyography; Evoked Potentials, Motor; Female; Humans; Isometric Contraction/physiology; Migraine Disorders/physiopathology; Motor Cortex/physiology/physiopathology; Phosphenes; Physical Stimulation; Transcranial Magnetic Stimulation; Ulnar Nerve/physiology/physiopathology; Visual Cortex/physiology/physiopathology
Abstract :
[en] We performed transcranial magnetic stimulations of the motor and visual cortices in healthy controls (n = 27) and in patients suffering from migraine without (n = 33) or with (n = 25) aura between attacks. By using a 13-cm circular coil placed over the vertex and recordings of the first dorsal interosseus muscle, we measured thresholds (at rest and during contraction), amplitudes of motor evoked potentials and cortical silent periods. Paired stimulations with short (1-20 msec) interstimulus intervals were performed to assess intracortical inhibition. The visual cortex was stimulated with the same coil placed over the occipital scalp (7 cm above the inion) and the prevalence and threshold of phosphene production was determined. In patients with migraine with aura, motor thresholds during isometric contraction were significantly higher, whereas the prevalence of stimulation-induced phosphene production was lower compared with healthy controls. These changes were not correlated with attack frequency or disease duration. No differences were found between subject groups in thresholds at rest, motor evoked potential amplitudes, cortical silent periods, or response curves after paired stimuli. These results are in favor of cortical hypoexcitability rather than hyperexcitability in patients with migraine with aura between attacks.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Afra, Judit
Mascia, Adolores
GERARD, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
MAERTENS DE NOORDHOUT, Alain  ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Interictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices.
Publication date :
1998
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, New York, United States - New York
Volume :
44
Issue :
2
Pages :
209-15
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 September 2009

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