ORBi: Zhang Lixin - The multivariate coefficient of variation for comparing serum protein electrophoresis techniques in External Quality Assessment schemes

Reference : The multivariate coefficient of variation for comparing serum protein electrophoresis te...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Public health, health care sciences & services Human health sciences : Laboratory medicine & medical technology
	To cite this reference:	http://hdl.handle.net/2268/2444

Title :	The multivariate coefficient of variation for comparing serum protein electrophoresis techniques in External Quality Assessment schemes
Language :	English
Author, co-author :	Zhang, Lixin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
	Albarède, Stéphanie [Direction de l'Évaluation des DIspositifs Médicaux (DEDIM) > > Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSaPS) > >]
	Dumont, Gilles [Direction de l'Évaluation des DIspositifs Médicaux (DEDIM) > > Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSaPS) > >]
	Van Campenhout, Christel [> Department of Clinical Biology > Belgian Scientific Institute of Public Health > >]
	Libeer, Jean-Claude [> Department of Clinical Biology > Belgian Scientific Institute of Public Health > >]
	Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique >]
Publication date :	2010
Journal title :	Accreditation and Quality Assurance
Publisher :	Springer
Audience :	International
ISSN :	0949-1775
e-ISSN :	1432-0517
Keywords :	[en] Analytical variability ; Electrophoretic techniques ; EQA schemes ; Equipment performance ; Reproducibility ; Test profiles
Abstract :	[en] External Quality Assessment (EQA) schemes are national or transnational programmes designed to control the analytical performance of clinical laboratories and to maintain inter-laboratory variability within acceptable limits. In such EQA programmes, participants are usually grouped by the type of assay technique/equipment they use. The coefficient of variation (CV) is a simple tool for comparing the inter-laboratory reproducibility of such techniques: the lower the CV, the better the analytical performance. Serum protein electrophoresis, a laboratory test profile consisting of five fractions (albumin, α1, α2, β and γ globulins) summing up to 100% of total proteins, can also be assayed in different ways depending on the media or the analytical principle. We propose a multivariate coefficient of variation for comparing the performance of electrophoretic techniques in EQA, thus extending the univariate CV concept. First, the compositional nature of electrophoretic data requires a one-to-one transformation from the 5-dimensional to the 4-dimensional space. Next, robust estimations of the mean and the covariance matrix are needed to avoid the effect of outliers. The new approach is illustrated on electrophoretic datasets from the French and Belgian national EQA programmes.
Target :	Researchers ; Professionals ; General public
Permalink :	http://hdl.handle.net/2268/2444
DOI :	10.1007/s00769-009-0627-3
Other URL :	http://www.springerlink.com/content/c724365316516062/

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Open access	Zhang et al Accred Qual Assur (final version 10-12-2009) .pdf		Author preprint	363.06 kB	View/Open

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