Article (Scientific journals)
Pathbase: a database of mutant mouse pathology
Schofield, P. N.; Bard, J. B. L.; Booth, C. et al.
2004In Nucleic Acids Research, 32 (Sp. Iss. SI), p. 512-D515
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Abstract :
[en] Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted multagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Schofield, P. N.
Bard, J. B. L.
Booth, C.
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Covelli, V.
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Ellender, M.
Engstrom, W.
Goessner, W.
Gruenberger, M.
Hoefler, H.
Hopewell, J.
Mancuso, M.
Mothersill, C.
Potten, C. S.
Quintanilla-Fend, L.
Rozello, B.
Sariola, H.
Sundberg, J. P.
Ward, A.
More authors (10 more) Less
Language :
English
Title :
Pathbase: a database of mutant mouse pathology
Publication date :
01 January 2004
Journal title :
Nucleic Acids Research
ISSN :
0305-1048
eISSN :
1362-4962
Publisher :
Oxford Univ Press, Oxford, United Kingdom
Volume :
32
Issue :
Sp. Iss. SI
Pages :
D512-D515
Peer reviewed :
Peer Reviewed verified by ORBi
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