Reference : Differential production of cytokines and activation of NF-kappa B in HPV-transformed ker...

	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/24362

Title :	Differential production of cytokines and activation of NF-kappa B in HPV-transformed keratinocytes
Language :	English
Author, co-author :	Havard, L. [> > > >]
	Delvenne, Philippe [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
	Frare, P. [> > > >]
	Boniver, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
	Giannini, S. L. [> > > >]
Publication date :	5-Jul-2002
Journal title :	Virology
Publisher :	Academic Press Inc Elsevier Science
Volume :	298
Issue/season :	2
Pages :	271-285
Audience :	International
ISSN :	0042-6822
City :	San Diego
Abstract :	[en] We have proposed that chronic infection of keratinocytes by HPV modifies the expression of potentially important cytokines by interfering with the NF-kappaB signal pathway We evaluated the constitutive and IL-1beta-induced expression of GM-CSF and TNF-alpha and the expression/activity of NF-kappaB in HPV+ and HPV- cell lines. Despite the enhanced expression of the functional components of the NF-kappaB signaling pathway in HPV+ cell lines by a mechanism implicating the HPV oncoprotein E6, the constitutive activity of NF-kappaB and the expression of GM-CSF/TNF-alpha were significantly reduced relative to the HPV- cell line and normal keratinocytes. In contrast, we observed a superactivation of NF-kappaB activity after IL-1beta stimulation, a strong and transient induction of GM-CSF/TNF-alpha mRNA, but undetectable levels of secreted proteins in HPV+ cell lines. Our data demonstrate that E6 modulates the NF-kappaB signaling pathway and suggest that other HPV proteins also interfere with GM-CSF/TNF-alpha expression by transcriptional and/or posttranscriptional mechanisms. (C) 2002 Elsevier Science (USA).
Permalink :	http://hdl.handle.net/2268/24362

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