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Article (Scientific journals)
Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Pardutz, A.; Krizbai, I.; Multon, Sylvie et al.
2000In Neuroreport, 11 (14), p. 3071-5
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Keywords :
Animals; Cell Count; Cerebral Arteries/drug effects/innervation/metabolism; Cerebrovascular Circulation/drug effects/physiology; Disease Models, Animal; Male; Migraine Disorders/metabolism/pathology/physiopathology; Neurons/cytology/drug effects/metabolism; Nitric Oxide/metabolism; Nitric Oxide Synthase/drug effects/metabolism; Nitroglycerin/pharmacology; Nociceptors/cytology/drug effects/metabolism; Pain Measurement; Proto-Oncogene Proteins c-fos/metabolism; Rats; Rats, Wistar; Trigeminal Caudal Nucleus/cytology/drug effects/metabolism
Abstract :
[en] Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine.
Disciplines :
Neurosciences & behavior
Neurology
Author, co-author :
Pardutz, A.
Krizbai, I.
Multon, Sylvie ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Vecsei, L.
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Publication date :
2000
Journal title :
Neuroreport
ISSN :
0959-4965
eISSN :
1473-558X
Publisher :
Lippincott Williams & Wilkins, London, United Kingdom
Volume :
11
Issue :
14
Pages :
3071-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 September 2009

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