|Reference : From neurophysiology to genetics: cortical information processing in migraine underlies ...|
|Scientific journals : Article|
|Human health sciences : General & internal medicine|
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
|From neurophysiology to genetics: cortical information processing in migraine underlies familial influences--a novel approach|
|Sandor, P. S. [> > > >]|
|Afra, J. [> > > >]|
|Proietti Cecchini, A. P. [> > > >]|
|Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique]|
|Schoenen, Jean [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]|
|CIC Edizioni Internationali|
|[en] Adolescent ; Adult ; Auditory Cortex/physiology ; Cerebral Cortex/physiology ; Evoked Potentials, Auditory/physiology ; Evoked Potentials, Visual/genetics/physiology ; Female ; Habituation, Psychophysiologic/genetics/physiology ; Humans ; Male ; Mental Processes/physiology ; Middle Aged ; Migraine Disorders/genetics/physiopathology|
|[en] Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors.|
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