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Article (Scientific journals)
Subclinical cerebellar impairment in the common types of migraine: a three-dimensional analysis of reaching movements.
Sandor, P. S.; Mascia, A.; SEIDEL, Laurence et al.
2001In Annals of Neurology, 49 (5), p. 668-72
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Keywords :
Adult; Arm/physiopathology; Cerebellar Diseases/physiopathology; Female; Humans; Male; Migraine Disorders/physiopathology; Movement/physiology
Abstract :
[en] Mutations in the CACNA1A gene can cause familial hemiplegic migraine (FHM) and/or cerebellar ataxia CACNA1A codes for the alpha1 subunit of P/Q-Ca2+ channels and is highly expressed in the cerebellum. Using a pointing paradigm and infrared optoelectronic tracking system, we found subclinical hypermetria and other subtle cerebellar signs in the common forms of migraine. These were more pronounced in migraine with than without aura. Whether this reflects involvement of Ca2+ channel genes in the common types of migraine needs to be investigated by genetic analyses.
Disciplines :
Neurology
Neurosciences & behavior
Author, co-author :
Sandor, P. S.
Mascia, A.
SEIDEL, Laurence  
De Pasqua, Victor ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Subclinical cerebellar impairment in the common types of migraine: a three-dimensional analysis of reaching movements.
Publication date :
2001
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., New York, United States - New York
Volume :
49
Issue :
5
Pages :
668-72
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 September 2009

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