[en] Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The amplitude of the P50 response to the second of two homologous stimuli was significantly less reduced in migraineurs than in healthy volunteers. This lack of auditory sensory gating may be due to a hypofunction of monoaminergic subcortico-cortical pathways, which is also supposed to cause the interictal deficit of cortical habituation to repetitive stimuli.
Disciplines :
Neurology Neurosciences & behavior
Author, co-author :
Ambrosini, A.
De Pasqua, Victor ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Afra, J.
Sandor, P. S.
Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Language :
English
Title :
Reduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing?
Adler L.E., Patchman E., Franks R.D., Pecevich M., Waldo M.C., Freedman R. (1982) Neurophysiological gating in schizophrenia. Biol. Psychiatry 17:639-654.
Bahra A., Matharu M.S., Buchel C., Frackowiak R.S.J., Goadsby P.J. (2001) Brainstem activation specific to migraine headache. Lancet 357:1016-1017.
Bickford-Wimer P.C., Nagamoto H., Johnson R., Adler L.E., Egan M., Rose G.M., Freedman R. (1990) Auditory sensory gating in hippocampal neurons: A model system in the rat. Biol. Psychiatry 27:183-192.
Boutros N.N., Torello M.W., Barker B.A., Tueting P.A., Wu S.C., Nasrallah H.A. (1995) The P50 evoked potential component and mismatch detection in normal volunteers: Implications for the study of sensory gating. Psychiatry Res 57:83-88.
(1988) Classification and diagnostic criteria for the headache disorders, cranial neuralgias and facial pain. Cephalalgia 8(S7):1-96.
Hegerl U., Juckel G. (1993) Intensity depedence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesis. Biol. Psychiatry 33:173-187.
Jin Y., Potkin S.G., Patterson J.V., Sandman C.A., Hetrick W.P., Bunney W.E. Jr. (1997) Effects of P50 temporal variability on sensory gating in schizophrenia. Psychiatry Res 70:71-81.
Judit A., Sandor P., Schoenen J. (2000) Habituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack. Cephalalgia 20:714-719.
Miyazato H., Skinner R.D., Crews T., Williams K., Garcia-Rill E. (2000) Serotonergic modulation of the P13 midlatency auditory evoked potential in the rat. Brain Res. Bull. 51:387-391.
Miyazato H., Skinner R.D., Garcia-Rill E. (1999) Neurochemical modulation of the P13 midlatency auditory evoked potential in the rat. Neuroscience 92:911-920.
Reese N.B., Garcia-Rill E., Skinner R.D. (1995) Auditory input to the pedunculopontine nucleus: I. Evoked potentials. Brain Res. Bull. 37:257-264.
Schoenen J., Wang W., Albert A., Delwaide P.J. (1995) Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks. Eur. J. Neurol. 2:115-122.
Wang W., Timsit-Berthier M., Schoenen J. (1996) Intensity dependence of auditory evoked potentials is pronounced in migraine: An indication of cortical potentiation and low serotonergic neurotransmission?. Neurology 46:1404-1409.
Weiller C., May A., Limmroth V., Juptner M., Kaube H., Schayck R.V., Coenen H.H., Diener H.C. (1995) Brain stem activation in spontaneous human migraine attacks. Nat. Med. 1:658-660.
