Reference : Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
http://hdl.handle.net/2268/24177
Acetazolamide acts on neuromuscular transmission abnormalities found in some migraineurs.
English
Ambrosini, A. [> > > >]
Pierelli, F. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
2003
Cephalalgia : An International Journal of Headache
Blackwell Science
23
2
75-8
Yes (verified by ORBi)
International
0333-1024
1468-2982
Osney Mead Oxford
United Kingdom
[en] Acetazolamide/administration & dosage ; Adult ; Calcium Channels, N-Type ; Electromyography/methods ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Migraine with Aura/complications/diagnosis/drug therapy/physiopathology ; Neuromuscular Junction/drug effects/physiopathology ; Neuromuscular Junction Diseases/complications/diagnosis/drug therapy/physiopathology ; Synapses/drug effects ; Treatment Outcome
[en] Mild subclinical impairment of neuromuscular transmission can be detected with single-fibre electromyography (SFEMG) in subgroups of patients suffering from migraine and could be due to dysfunctioning Ca2+-channels on motor axons controlling stimulation-induced acetylcholine release. Acetazolamide, which is thought to ameliorate ion channel function, was shown effective in familial hemiplegic migraine and episodic ataxia type 2, both of which are associated with mutations of the neuronal Ca2+-channel gene CACNA1A, as well as in aura status. We treated therefore in an open pilot study five non-hemiplegic migraineurs showing mild SFEMG abnormalities with acetazolamide for several weeks. This was followed by a normalization of SFEMG recordings in all patients and by clinical improvement in four. These results support the assumption that the subclinical impairment of neuromuscular transmission found in certain migraineurs might be due to dysfunctioning Ca2+-channels.
http://hdl.handle.net/2268/24177

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