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| Reference : Human Anti-Alpha-Galactosyl Igg Reduces the Lung Colonization by Murine Mo4 Cells |
| Scientific journals : Article | |||
| Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/24150 | |||
| Human Anti-Alpha-Galactosyl Igg Reduces the Lung Colonization by Murine Mo4 Cells | |
| English | |
Castronovo, Vincenzo  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >] | |
| Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >] | |
| Li Vecchi, M. [> > > >] | |
| Foidart, J. B. [> > > >] | |
| Bracke, M. [> > > >] | |
| Mareel, M. [> > > >] | |
| Mahieu, P. [> > > >] | |
| 1987 | |
| Invasion & Metastasis | |
| 7 | |
| 6 | |
| 325-45 | |
| International | |
| 0251-1789 | |
| [en] The lung colonization of MO4 cells, a highly malignant murine cell line, is strongly reduced in syngeneic C3H/He mice by a prior incubation with anti-alpha-galactosyl antibody (alpha-Gal Ab), a natural IgG antibody present in high titers in all normal human sera and specifically recognizing Gal alpha(1----3) structures (alpha-D-galactopyranosyl; alpha-D-Galp). The protective effect is due to a binding of alpha-Gal Ab to alpha-D-Galp end groups of MO4 cells, inducing both an increase in their sequestration into the liver and the spleen and a decrease in their sequestration into the lung. The F(ab')2 fragments of this antibody also exhibit a protective effect by inhibiting the homing of MO4 cells into the lung, without modifying their accumulation into the spleen and the liver. Since both the antibody and the alpha-galactosidase pretreatments of MO4 cells block their subsequent attachment to murine laminin in vitro, we suggest that, in this model, the lung colonization may be dependent on the alpha-D-Galp end groups exposed on the surface of MO4 cells. | |
| http://hdl.handle.net/2268/24150 |
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