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| Reference : Possible Role of Human Natural Anti-Gal Antibodies in the Natural Antitumor Defense System |
| Scientific journals : Article | |||
| Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology | |||
| http://hdl.handle.net/2268/24131 | |||
| Possible Role of Human Natural Anti-Gal Antibodies in the Natural Antitumor Defense System | |
| English | |
Castronovo, Vincenzo  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >] | |
| Colin, Claude [Université de Liège - ULg > > Gynécologie - Obstétrique >] | |
| Parent, B. [> > > >] | |
| Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >] | |
| Lambotte, René [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >] | |
| Mahieu, P. [> > > >] | |
| 1-Feb-1989 | |
| Journal of the National Cancer Institute | |
| 81 | |
| 3 | |
| 212-6 | |
| International | |
| 0027-8874 | |
| [en] Expression of Gal alpha 1-3Gal cell surface residues has been correlated with the metastatic potential of murine tumor cells. We report that Gal alpha 1-3Gal residues are expressed at the cell surface of malignant human cancer cells, including four cell lines and 50% of the malignant breast specimens obtained by aspiration biopsy. In contrast, all benign breast biopsies and normal cells were Gal alpha 1-3Gal negative. Affinity-purified anti-alpha-galactosyl IgG (anti-Gal) antibody, which specifically recognizes Gal alpha 1-3Gal residues, significantly inhibited cell attachment in two in vitro assays thought to indicate tumor cell extravasation of the circulatory system during the metastatic process: attachment to perfused human umbilical vein endothelium, and attachment to isolated laminin. Since anti-Gal antibody is a natural component of all human sera, we propose that it may be part of the natural antitumor defense system in humans. | |
| http://hdl.handle.net/2268/24131 |
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