|Reference : Possible Role of Human Natural Anti-Gal Antibodies in the Natural Antitumor Defense System|
|Scientific journals : Article|
|Human health sciences : Oncology|
Life sciences : Biochemistry, biophysics & molecular biology
|Possible Role of Human Natural Anti-Gal Antibodies in the Natural Antitumor Defense System|
|Castronovo, Vincenzo [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]|
|Colin, Claude [Université de Liège - ULg > > Gynécologie - Obstétrique >]|
|Parent, B. [> > > >]|
|Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique >]|
|Lambotte, René [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]|
|Mahieu, P. [> > > >]|
|Journal of the National Cancer Institute|
|[en] Expression of Gal alpha 1-3Gal cell surface residues has been correlated with the metastatic potential of murine tumor cells. We report that Gal alpha 1-3Gal residues are expressed at the cell surface of malignant human cancer cells, including four cell lines and 50% of the malignant breast specimens obtained by aspiration biopsy. In contrast, all benign breast biopsies and normal cells were Gal alpha 1-3Gal negative. Affinity-purified anti-alpha-galactosyl IgG (anti-Gal) antibody, which specifically recognizes Gal alpha 1-3Gal residues, significantly inhibited cell attachment in two in vitro assays thought to indicate tumor cell extravasation of the circulatory system during the metastatic process: attachment to perfused human umbilical vein endothelium, and attachment to isolated laminin. Since anti-Gal antibody is a natural component of all human sera, we propose that it may be part of the natural antitumor defense system in humans.|
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