ORBi: Gorski A. - Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular Matrix Interactions

Reference : Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular Ma...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Oncology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/24124

Title :	Depressed Immune Surveillance against Cancer: Role of Deficient T Cell: Extracellular Matrix Interactions
Language :	English
Author, co-author :	Gorski, A. [> > > >]
	Castronovo, Vincenzo [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
	Stepien-Sopniewska, B. [> > > >]
	Grieb, P. [> > > >]
	Ryba, M. [> > > >]
	Mrowiec, T. [> > > >]
	Korczak-Kowalska, G. [> > > >]
	Wierzbicki, P. [> > > >]
	Matysiak, W. [> > > >]
	Dybowska, B. [> > > >]
	et al. [> > > >]
Publication date :	Jul-1994
Journal title :	Cell Adhesion and Communication
Volume :	2
Issue/season :	3
Pages :	225-33
Audience :	International
ISSN :	1061-5385
Keywords :	[en] cancer ; extracellular matrix ; adhesion ; co-stimulation ; T cells ; collagen IV ; fibronectin
Abstract :	[en] Although T cells infiltrate malignant tumors, the local immune response is usually inefficient and tumors escape destruction. While extracellular matrix proteins strongly costimulate T cell responses in normal individuals, our studies indicate that peripheral blood T cells from cancer patients and tumor infiltrating cells respond poorly or are resistant to stimulative signals mediated by collagen I and IV and fibronectin. Moreover, the adhesive properties of cancer T cells are markedly depressed. Those functional deficiencies are paralleled by variable deficits in integrin and non-integrin T cell receptors for extracellular matrix. Immunotherapy with BCG causes a dramatic but transient increase in T cell: ECM interactions.
Funders :	BIOMED BMH1-CT92-0520 ; Warsaw Medical School intramural grants VI/d1 and VIId/11
Permalink :	http://hdl.handle.net/2268/24124

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