You are here:
| Reference : Galectin-1 Modulates Human Melanoma Cell Adhesion to Laminin |
| Scientific journals : Article | |||
| Life sciences : Biochemistry, biophysics & molecular biology Human health sciences : Oncology | |||
| http://hdl.handle.net/2268/24105 | |||
| Galectin-1 Modulates Human Melanoma Cell Adhesion to Laminin | |
| English | |
| van den Brule, F. A. [> > > >] | |
| Buicu, C. [> > > >] | |
| Baldet, M. [> > > >] | |
| Sobel, M. E. [> > > >] | |
| Cooper, D. N. [> > > >] | |
| Marschal, P. [> > > >] | |
Castronovo, Vincenzo  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >] | |
| 17-Apr-1995 | |
| Biochemical and Biophysical Research Communications | |
| 209 | |
| 2 | |
| 760-7 | |
| International | |
| 0006-291X | |
| [en] Galectins constitute a gene family of beta-galactoside-specific lectins that show high homology in their carbohydrate-binding site. They have been postulated to be involved in many biological events, but their specific functions are not yet well defined. Galectin-1 is a laminin binding protein that recognizes poly-N-acetyllactosamine chains on this major basement membrane glycoprotein. In this study, we analyzed the possibility that galectin-1 could modulate interactions between human melanoma cells and laminin. We demonstrated that A375 and A2058 cell lines express galectin-1 both intracellularly and on the cell surface. In an in vitro assay, recombinant galectin-1 increased melanoma cell attachment to laminin in a dose-dependent manner. This effect was abolished by lactose. Anti-galectin-1 inhibited adhesion of melanoma cells to laminin in a dose-dependent fashion. However, neither galectin-1 nor anti-galectin-1 antibody affected melanoma cell spreading on laminin in vitro. These data indicate that galectin-1 might participate in melanoma cell adhesion to laminin and therefore could be a modulator of invasion and metastasis. | |
| European BIOMED BMH1-CT92-0520 | |
| http://hdl.handle.net/2268/24105 |
| File(s) associated to this reference | ||||||||||||||
|
Fulltext file(s):
| ||||||||||||||
All documents in ORBi are protected by a user license.
