The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution.

Amino Acid Sequence; Animals; Binding Sites/genetics; Evolution, Molecular; Humans; Laminin/metabolism; Molecular Sequence Data; Molecular Weight; Neoplasms/genetics; Phylogeny; Protein Precursors/chemistry/genetics/metabolism; Receptors, Laminin/chemistry/genetics/metabolism; Ribosomal Proteins/chemistry/genetics; Sequence Homology, Amino Acid

Abstract :

[en] The 67-kDa laminin receptor (67LR) is a nonintegrin cell surface receptor that mediates high-affinity interactions between cells and laminin. Overexpression of this protein in tumor cells has been related to tumor invasion and metastasis. Thus far, only a full-length gene encoding a 37-kDa precursor protein (37LRP) has been isolated. The finding that the cDNA for the 37LRP is virtually identical to a cDNA encoding the ribosomal protein p40 has suggested that 37LRP is actually a component of the translational machinery, with no laminin-binding activity. On the other hand, a peptide of 20 amino acids deduced from the sequence of 37LR/p40 was shown to exhibit high laminin-binding activity. The evolutionary relationship between 23 sequences of 37LRP/p40 proteins was analyzed. This phylogenetic analysis indicated that all of the protein sequences derive from orthologous genes and that the 37LRP is indeed a ribosomal protein that acquired the novel function of laminin receptor during evolution. The evolutionary analysis of the sequence identified as the laminin-binding site in the human protein suggested that the acquisition of the laminin-binding capability is linked to the palindromic sequence LMWWML, which appeared during evolution concomitantly with laminin.

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology

Author, co-author :

Ardini, E.

Pesole, G.

Tagliabue, E.

Magnifico, A.

Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire - GIGA-R : Labo de recherche sur les métastases

Sobel, M. E.

Colnaghi, M. I.

Menard, S.

Language :

English

Title :

The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution.

Publication date :

1998

Journal title :

Molecular Biology and Evolution

ISSN :

0737-4038

eISSN :

1537-1719

Publisher :

Oxford University Press, New York, United States - New York

Volume :

Issue :

Pages :

1017-25

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

AIRC/FIRC
EU Project BIO4-CT95-0130

Available on ORBi :

since 28 September 2009

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