Reference : Tnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Fun...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/24090
Tnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Functional 37lrp/P40 Gene and Protein in Transformed Keratinocytes
English
Clausse, Nathalie [> > > >]
van den Brûle, Frédéric [> > > >]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Franzen-Detrooz, Elisabeth [> > > >]
Jackers, Pascale [Université de Liège - ULg > > Centre interfac. d'analyse des résidus en traces (CART) >]
Castronovo, Vincenzo mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
20-Oct-1998
Biochemical and Biophysical Research Communications
251
2
564-9
Yes (verified by ORBi)
International
0006-291X
[en] 37 LRP/p40 ; 67LR ; bi-functional
[fr] metastasis-associated ; TNF-alpha ; IFN-gamma
[en] The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-alpha and IFN-gamma. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-gamma and TNF-alpha anticancerous action.
Centre Anticancéreux près l'Université de Liège ; Association Sportive contre le Cancer ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/24090
10.1006/bbrc.1998.9431

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