Article (Scientific journals)
Tnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Functional 37lrp/P40 Gene and Protein in Transformed Keratinocytes
Clausse, Nathalie; van den Brûle, Frédéric; Delvenne, Philippe et al.
1998In Biochemical and Biophysical Research Communications, 251 (2), p. 564-9
Peer reviewed
 

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Keywords :
37 LRP/p40; 67LR; bi-functional; metastasis-associated; TNF-alpha; IFN-gamma
Abstract :
[en] The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-alpha and IFN-gamma. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-gamma and TNF-alpha anticancerous action.
Disciplines :
Oncology
Author, co-author :
Clausse, Nathalie
van den Brûle, Frédéric
Delvenne, Philippe ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Jacobs, Nathalie  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Franzen-Detrooz, Elisabeth
Jackers, Pascale ;  Université de Liège - ULiège > Centre interfac. d'analyse des résidus en traces (CART)
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Language :
English
Title :
Tnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Functional 37lrp/P40 Gene and Protein in Transformed Keratinocytes
Publication date :
20 October 1998
Journal title :
Biochemical and Biophysical Research Communications
ISSN :
0006-291X
eISSN :
1090-2104
Publisher :
Elsevier, Atlanta, United States - California
Volume :
251
Issue :
2
Pages :
564-9
Peer reviewed :
Peer reviewed
Funders :
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
Association Sportive contre le Cancer
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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