Reference : The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volu...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
Human health sciences : Neurology
http://hdl.handle.net/2268/2390
The Effect of Clonidine Infusion on Distribution of Regional Cerebral Blood Flow in Volunteers
English
Bonhomme, Vincent [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques]
Maquet, Pierre mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Phillips, Christophe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Hans, Pol [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Lamy, Maurice mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Mar-2008
Anesthesia and Analgesia
Lippincott Williams & Wilkins
106
3
899-909
Yes (verified by ORBi)
International
0003-2999
1526-7598
Baltimore
MD
[en] BACKGROUND: Through their action on the locus coeruleus, alpha2-adrenoceptor agonists induce rapidly reversible sedation while partially preserving cognitive brain functions. Our goal in this observational study was to map brain regions whose activity is modified by clonidine infusion so as to better understand its loci of action, especially in relation to sedation. METHODS: Six ASA I-II right-handed volunteers were recruited. Electroencephalogram (EEG) was monitored continuously. After a baseline H2(15)O activation scan, clonidine infusion was started at a rate ranging from 6 to 10 microg x kg(-1) x h(-1). A sequence of 11 similar scans was then performed at 8 min intervals. Plasma clonidine concentration was measured. Using statistical parametric mapping, we sought linear correlations between normalized regional cerebral blood flow (rCBF), an indicator of regional brain activity, and plasma clonidine concentration or spindle EEG activity. RESULTS: Clonidine induced clinical sedation and EEG patterns (spindles) comparable to early stage nonrapid eye movement sleep. A significant negative linear correlation between clonidine concentration and rCBF or spindle activity was observed in the thalamus, prefrontal, orbital and parietal association cortex, posterior cingulate cortex, and precuneus. CONCLUSIONS: The EEG patterns and decreases in rCBF of specific brain regions observed during clonidine-induced sedation are similar to those of early stage nonrapid eye movement sleep. Patterns of deactivated brain regions are also comparable to those observed during general anesthesia or vegetative state, reinforcing the hypothesis that alterations in the activity of a common network occur during these modified conscious states.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/2390
also: http://hdl.handle.net/2268/2480
10.1213/ane.0b013e3181619685

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