Reference : Is the cerebral cortex hyperexcitable or hyperresponsive in migraine?
Scientific journals : Letter to the editor
Human health sciences : Neurology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/23808
Is the cerebral cortex hyperexcitable or hyperresponsive in migraine?
English
Coppola, G. [> > > >]
Pierelli, F. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Dec-2007
Cephalalgia : An International Journal of Headache
Blackwell Science
27
12
1429-1439
Yes (verified by ORBi)
International
0333-1024
[en] migraine ; hyperresponsivity ; evoked potentials ; transcranial magnetic stimulation ; habituation ; pathophysiology ; thalamocortical dysrhythmia
[en] Although migraineurs appear in general to be hypersensitive to external stimuli, they maybe also have increased daytime sleepiness and complain of fatigue. Neurophisiological studies between attacks have shown that for a number of different sensory modalities the migrainous brain is characterised by a lack of habituation of evoked responses. Whether this is due to increased cortical hyperexcitability, possibly due to decreased inhibition, or to an abnormal responsivity of the cortex due a decreased preactivation level remains disputed. Studies using transcranial magnetic stimulation in particular have yielded contradictory results. We will review here the available data on cortical excitability obtained with different methodological approaches in patients over the migraine cycle. We will show that these data congruently indicate that the sensory cortices of migraineurs react excessively to repetitive, but not to single, stimuli and that the controversy above hyper- versus hypo-excitability is merely a semantic misunderstanding. Describing the migrainous brain as 'hyperresponsive' would fit most of the available data. Deciphering the precise cellular and molecular underpinnings of this hyperresponsivity remains a challenge for future research. We propose, as a working hypothesis, that a thalamo-cortical dysrhythmia might be the culprit.
http://hdl.handle.net/2268/23808

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Is the cerebral cortex Coppola et al 2007.pdfPublisher postprint282.77 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.