Reference : Morphological alterations in oxidative muscles and mitochondrial structure associated wi...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/2377
Morphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy
English
Cassart, Dominique mailto [Université de Liège - ULg > Département de morphologie et pathologie > Département de morphologie et pathologie >]
Baise, Etienne mailto [Université de Liège - ULg > Département des sciences de la vie > Macromolécules biologiques >]
Cherel, Yann [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
Delguste, Catherine mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Scientifiques attachés au Doyen (F MV) >]
Antoine, Nadine mailto [Université de Liège - ULg > Département de morphologie et pathologie > Histologie >]
Votion, Dominique mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Amory, Hélène mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés >]
Rollin, Frédéric mailto [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs >]
Linden, Annick mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Santé et pathologies de la faune sauvage >]
Coignoul, Freddy mailto [Université de Liège - ULg > Services administratifs généraux > Vice-Recteur à la Qualité >]
Desmecht, Daniel mailto [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Jan-2007
Equine Veterinary Journal
Equine Veterinary Journal Ltd
39
1
26-32
Yes (verified by ORBi)
International
0425-1644
Newmarket Suffolk
United Kingdom
[en] myopathy ; horse ; mitochondria
[en] REASONS FOR PERFORMING STUDY: There is a lack of well documented studies about muscular lesions in equine atypical myopathy (EAM).
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<br />OBJECTIVES: To characterise morphopathological changes of striated muscles and myocardium, to progress understanding of this disease.
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<br />METHODS: Thirty-two horses age 0.5-7 years kept on pasture were referred for a sudden ataxia/myoglobinuria syndrome. Clinical examination (stiffness, muscle pain, muscle fasciculations, abnormal gait, recumbency, myoglobinuria, tachycardia, sweating) and plasma CPK, LDH and AST levels were consistent with extensive myonecrosis and, together with anamnestic data, with so-called 'equine atypical myopathy' (EAM), a disease of unknown aetiology reported since 1939. Macroscopic and microscopic (histology, histoenzymology, ultrastructure) lesions were evaluated.
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<br />RESULTS: Necropsic examination revealed large areas of muscle necrosis, the extent and severity of which varied between cases and muscles, but which were clearly more constant and severe in respiratory and postural muscles and in the myocardium. Histology highlighted a multifocal and monophasic process compatible with Zenker degeneration/necrosis that mostly and segmentally affected type 1 fibres. Histochemical evaluation revealed a weak and disorganised pattern of NADH tetrazolium reductase staining, the absence of calcium salts precipitates and a dramatic accumulation of lipid droplets. Ultrastructural examination often revealed fibres of which the sole modifications were altered mitochondria and sarcoplasmic lipidosis.
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<br />CONCLUSIONS: Taken together, the data suggest that a primary alteration of mitochondria should be considered, although secondary mitochondrial abnormalities have yet to be ruled out.
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<br />POTENTIAL RELEVANCE: The morphological features gathered here reveal that EAM shares most of the characteristics of toxic myopathies.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/2377
also: http://hdl.handle.net/2268/108785 ; http://hdl.handle.net/2268/32974 ; http://hdl.handle.net/2268/61158

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