[en] The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda Buck received in 2004 the Nobel Prize for discovering the G-protein coupled receptors role in olfactory cells, it highlighted the importance of olfaction to scientific community. Several theories tried to explain how cells are able to distinguish such a wide variety of odorant molecules in a complex context in which enantiomers can result in completely different perceptions and structurally different molecules in the same one. Moreover, sex, age, cultural origin and individual differences contribute to odor perception variations that complicate the picture. Recent advances in olfaction theory will be presented and future trends in human olfaction like structure-based odor prediction or artificial sniffing will be discussed at the frontiers of chemistry, physiology, neurobiology and machine learning.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Genva, Manon ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Kenne Kemene, Tierry ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Deleu, Magali ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Lins, Laurence ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Fauconnier, Marie-Laure ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Language :
English
Title :
Is it possible to predict the odor of a molecule on the basis of its structure?
Publication date :
20 June 2019
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
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