Article (Scientific journals)
Blunted response of growth hormone to clonidine and apomorphine in endogenous depression
Ansseau, Marc; von Frenckell, Rémy; Cerfontaine, Jean-Luc et al.
1988In British Journal of Psychiatry, 153 (1), p. 65-71
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Keywords :
Depressive Disorder; Growth Hormone; Blood Pressure
Abstract :
[en] We measured the growth hormone (GH) response to clonidine (an alpha-2-adrenergic agonist) and to apomorphine (a dopaminergic agonist) in 15 major endogenous and 15 minor depressive in-patients matched for gender and age. Results showed a significantly smaller GH response in the major depressives to both clonidine (P less than 0.01) and apomorphine (P less than 0.001). No significant difference existed between the two groups with regard to changes in blood pressure and pulse rate during either test. While major depressives showed a trend toward smaller sedative side-effects than minor depressives after clonidine, they showed significantly smaller sedative and gastro-intestinal side-effects after apomorphine. No significant correlation was present either in the major depressive or in the minor depressive group between the GH responses following clonidine and apomorphine challenges. These results support the hypothesis of both noradrenergic and dopaminergic neurotransmitter disturbances in major depression, with individual variability with regard to those biochemical anomalies.
Disciplines :
Psychiatry
Author, co-author :
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
von Frenckell, Rémy ;  Université de Liège - ULiège > Psychiatrie et psychologie médicale
Cerfontaine, Jean-Luc;  Université de Liège - ULiège > Service de Neuropsychiatrie
Papart, Patrick ;  Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale
Franck, Georges ;  Université de Liège - ULiège > Psychologie médicale et psychiatrie dynamique
Timsit-Berthier, Martine ;  Université de Liège - ULiège > Neurophysiologie & Psychopathologie
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie - Embryologie
Legros, Jean-Jacques ;  Université de Liège - ULiège > Endocrinologie clinique
Language :
English
Title :
Blunted response of growth hormone to clonidine and apomorphine in endogenous depression
Publication date :
1988
Journal title :
British Journal of Psychiatry
ISSN :
0007-1250
eISSN :
1472-1465
Publisher :
Royal College of Psychiatrists, London, United Kingdom
Volume :
153
Issue :
1
Pages :
65-71
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 September 2009

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