[en] A double-blind study combining electrophysiological and psychometrical approaches was carried out to investigate the central effects of an intravenous oxytocin (OT) infusion in normal men. Contingent negative variation (CNV) was selected as the measure of central cognitive evoked potential, and the psychometric tests measured mood, vigilance and memory. OT infusion induced a significant decrease of CNV amplitude and an increase of post-imperative positive potentials in vertex derivations. A similar effect was still evidenced one week after treatment in frontal derivations, suggesting a long time effect of OT on human brain. No significant influence of OT on mood or vigilance tests was apparent; only one item of a memory test revealed a significant impairment of some mnesic performances. These observations provide new electrophysiological arguments supporting a central action of peripheral OT administration in man.
Disciplines :
Neurology
Author, co-author :
Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie
Adam, Francine; Université de Liège - ULiège > Psychoneuroendocrinologie
Ader, de Wied (1972) Effects of lysine vasopressin on passive avoidance learning. Psychonomic Science 29:46-48.
Ansseau, Doumont, Cerfontaine, Mantanus, Rousseau, Timsit-Berthier (1984) Self-reports of anxiety level and EEG changes after a single dose of benzodiazepine. Neuropsychobiology 12:255-259.
Ansseau, Legros, Mormont, Cerfontaine, Papart, Geenen, Adam, Franck (1987) Intranasal oxytocin in obsessive-compulsive disorder: a case report. Psychoneuroendocrinology 12:231-236.
Beckwith, Petros, Kanaan-Beckwith, Couk, Hang (1982) Vasopressin analog (DDAVP) facilitates concept learning in human males. Peptides 3:627-630.
Beckwith, Couk, Till (1983) Vasopressin analog influences the performance of males in a reaction time task. Peptides 4:707-709.
Blake, Dodd, Evans (1978) Vasopressin in amnesia. Lancet 1:608.
Bohus, Ader, de Wied (1972) Effects of vasopressin on active and passive avoidance behavior. Horm Behav 3:191-197.
Bohus, Urban, van Wimersma Greidanus, de Wied (1978) Opposite effects of oxytocin and arginine vasopressin on avoidance behavior and hippocampal theta rhythm in the rat. Neuropharmacology 17:239-247.
Bohus, Kovacs, de Wied (1978) Oxytocin, vasopressin and memory: opposite effects on consolidation and retrieval processes. Brain Res 157:414-417.
de Wied (1971) Long term effects of vasopressin on the maintenance of a conditioned avoidance response in the rat. Nature 232:58-60.
de Wied, Versteeg (1979) Neurohypophyseal principles and memory. Fed Proc 38:2348-2354.
Fehm-Wolfsdorf, Born, Voight, Fehm (1984) Human memory and neurohypophyseal hormones: Opposite effects of vasopressin and oxytocin. Psychoneuroendocrinology 9:289-292.
Ferrier, Kennett, Devlin (1980) Influence of oxytocin on human memory processes. Life Sci 27:2311-2317.
Gabor, Kovacs, Bohus, Versteeg, de Kloet, de Wied (1979) Effect of oxytocin and vasopressin on memory consolidation: sites of action and catecholaminergic correlates after local microinjection into limbic-midbrain structures. Brain Research 175:303-314.
Gold, Weingartner, Ballenger, Goodwin, Post (1979) Effects of 1-desamino-D-arginine vasopressin on behaviour and cognition in primary affective disorder. Lancett 2:992-994.
Hostetter, Jubb, Kozlowski (1977) Vasopressin affects the behavior of rats in a positively-rewarded discrimination task. Life Sciences 21:1321-1328.
Jenkins, Mather, Coughlan (1982) Effect of desmopressin on normal and impaired memory. J. Neurol Neurosurg Psychiat 45:830-831.
Kennett, Devlin, Ferrier (1982) Influence of oxytocin an human memory processes: validation by a control study. Life Sci 31:273-275.
Kovacs, Vecsei, Telegdy (1978) Opposite action of oxytocin to vasopressin in passive avoidance behavior in rats. Physiology & Behavior 20:801-801.
Kovacs, Telegdy (1983) Effects of oxytocin, des-glycinamide-oxytocin and anti-oxytocin serum on the α-MPT-induced disappearance of catecholamines in the rat brain. Brain Research 268:307-314.
Laczi, Valkusz, Laszlo, Wagner, Jardanhazy, Szasz, Szilard, Telegdy (1982) Effects of lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients. Psychoneuroendocrinology 7:185-193.
Laczi, Van Ree, Wagner, Valkusz, Jardanhazy, Kovacs, Telegdy, Szilard, Laszlo, de Wied (1983) Effects of desglycinamide-arginine-vasopressin (DGAVP) on memory processes in diabetes insipidus patients and non-diabetic subjects. Acta Endocrinol 102:205-212.
Legros, Gilot, Seron, Claessens, Adam, Moeglen, Audibert, Berchier (1978) Influence of vasopressin on learning and memory. Lancet 1:41-42.
Marczynski (1978) Neurochemical mechanisms in the genesis of slow potentials: a review and some clinical applications. Multidisciplinary Perspectives in Event-Related Brain Potential Research , D.A. Otto, U.S. Government Publishing Office/EPA, Washington DC; 25-35.
McCallum (1979) Cognitive aspects of slow potential changes. Cognitive Components in Cerebral Event-Related Potentials and Selective Attention , J.E. Desmedt, Karger, Basel; 151-171.
Muhlethaler, Sawyer, Manning, Dreifuss (1983) Characterization of a uterine-type oxytocin receptor in the rat hippocampus. Proc Natl Acad Sci USA 80:6713-6717.
Nebes, Reynolds, Horn (1984) The effect of vasopressin on memory in the healthy elderly. Psychiatry Res 11:49-59.
Peabody, Thiemann, Pigache, Miller, Berger, Yesavage, Tinklenberg (1985) Desglycinamide-9-arginine-8-vasopressin (DGAVP, Organon 5667) in patients with dementia. Neurobiol Aging 6:95-100.
Rebert (1980) Neurobehavioral aspects of brain slow potentials. Progr Brain Res 54:381-402.
Rey Les Troubles de la Memoire et Leur Examen Psychométrique, Dessart, Bruxelles; 1966.
Schulz, Kovacs, Telegdy (1974) Effect of physiological doses of vasopressin and oxytocin on avoidance behaviour and explaratory behaviour in rats. Acta Physiol Acad Sci Hung 45:211-215.
Skinner, Yingling (1977) Central gating mechanism that regulate event-related potentials and behaviour. A neural model for attention. Prog Clin Neurophysiol 1:30-69.
Skinner, King (1980) Electrogenesis of event-related slow potentials in the cerebral cortex of conscious animals. Rhythmic EEG Activities and Cortical Functioning , G. Pfurtscheller, P. Buser, C.A.S. Lopes da Silva, H. Petsche, Elsevier, Amsterdam; 21-32.
Squires, Halgren, Wilson, Crandall (1983) Human endogenous limbic potentials cross modality and depth/surface components in epileptic subjects. Adv Psychol 16:217-232.
Stuss, Benson The Frontal Lobes, Raven Press, New York; 1986.
Telegdy, Kovacs (1979) Role of monoamines in mediating the action of ACTH, vasopressin and oxytocin. Central Nervous System: Effects of Hypothalamic Hormones and Other Peptides , R. Collu, A. Barbeau, J.R. Ducharme, J.G. Rochefort, Raven Press, New York; 189-205.
Timsit-Berthier (1984) Variation contingente négative et composantes endogènes du potentiel évoqué. Rev EEG Neuroophysiol 14:77-96.
Timsit-Berthier, Gerono, Rousseau (1981) CNV and functional state changes during longlasting and repetitive recording sessions. Progr Brain: Res 54:673-681.
Timsit-Berthier, Mantanus, Devos, Spiegel (1982) Action of lysine vasopressin on human electrophysiological activity: night sleep pattern, auditory evoked potential, contingent negative variation. Neuropsychobiology 8:248-258.
Van Heuven-Nolsen, de Kloet, Versteeg (1984) Oxytocin affects utilisation of noradrenaline in distinct limbic-forebrain regions of the rat brain. Neuropharmacology 23:1373-1377.
Van Wimersma Greidanus, de Wied (1976) Dorsal hippocampus: A site of action of neuropeptides on avoidance behavior?. Pharmacology Biochemistry and Behavior 5:29-33.
Van Wimersma Greidanus, Dogterom, de Wied (1975) Intravenous administration of anti-vasopressin serum inhibits memory consolidation in rats. Life Sci 16:637-644.
Vranckx, Minne, Benghezal, Moeglen, Audibert (1979) Vasopressin and schizophrenia. Biological Psychiatry Today , J. Obiols, C. Baltus, E. Gonzales Monclus, J. Pujol, Elsevier, Amsterdam; 753-758.
Walter, Cooper, Aldridge, McCallum, Winter (1964) Contingent negative variation: an electrical sign of sensori-motor association and expectancy in the human brain. Nature 203:380-384.
Weingartner, Kaye, Gold, Smallberg, Petersen, Gillin, Ebert (1981) Vasopressin treatment of cognitive dysfunction in progressive dementia. Life Sci 29:2721-2726.
Weingartner, Gold, Ballenger, Smallberg, Summers, Rubinow, Post, Goodwin (1981) Effect of vasopressin on human memory function. Science 211:601-603.