[en] A 35-year-old woman with depression at-tempted suicide by taking an overdose of zimelidine (5 g), which was confirmed by zimelidine and norzimelidine plasma levels. Physical examination and repeat EKGs performed 2, 6, 9, and 12 hours later showed no alteration in her level of consciousness and only a slight increase in QT duration. However, the patient exhibited a distinct extrapyramidal syndrome, a finding consistent with animal data suggesting that zimelidine may possess some dopamine-receptor blockade properties.
Disciplines :
Psychiatry
Author, co-author :
Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Reynolds, Charles F. III; University of Pittsburgh School of Medicine > Western Psychiatric Institute and Clinic
Kupfer, David; University of Pittsburgh School of Medicine > Western Psychiatric Institute and Clinic
Doumont, Arlette; Université de Liège - ULiège > Pharmacologie
Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie - Embryologie
Dresse, Albert ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Juorio, Augusto; University of Saskatchewan > Psychiatrie
Language :
English
Title :
Extrapyramidal signs following zimelidine overdose
Publication date :
1985
Journal title :
Journal of Clinical Psychopharmacology
ISSN :
0271-0749
eISSN :
1533-712X
Publisher :
Williams and Wilkins, Baltimore, United States - Maryland
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