Article (Scientific journals)
Diagnostic performance of the thirty-four hour dexamethasone suppression test
Ansseau, Marc; Doumont, Adrienne; Cerfontaine, Jean-Luc et al.
1985In Psychoneuroendocrinology, 10, p. 215-219
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Keywords :
Circadian Rhythm; Depressive Disorder; Dexamethasone; Hydrocortisone
Abstract :
[en] The performance of the dexamethasone suppression test (DST) in the diagnostic confirmation of endogenous depression was compared according to two times of blood collection-1600 hr on day 2 (usual sample) and 0800 hr on day 3 (34 hr after dexamethasone intake)-in 14 endogenous depressives and in a control group of 17 psychiatric inpatients with other diagnoses. For the day 2 (1600 hr) sample, a 5 μg/dl cortisol concentration represented the best cut-off score, with sensitivity of 57% specificity of 88%, and diagnostic confidence of 80%. For the day 3 (0800 hr) sample, the best cut-off score was 20 μg/dl, with the same sensitivity (57%) but there was a decrease of both specificity (to 76%) and diagnostic confidence (to 67%). The mean cortisol levels were much higher on day 3 than on day 2, suggesting that the inhibitory activity of dexamethasone was no longer present.
Disciplines :
Psychiatry
Author, co-author :
Ansseau, Marc ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Doumont, Adrienne ;  Université de Liège - ULiège > Psychiatrie et psychologie médicale
Cerfontaine, Jean-Luc ;  Université de Liège - ULiège > Psychopharmacology Unit
Sulon, José;  Université de Liège - ULiège > Department of Clinical and Medical Pathology
Demey-Ponsart, Edmée;  Université de Liège - ULiège > Department of Clinical and Medical Pathology
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie - Embryologie
Legros, Jean-Jacques ;  Université de Liège - ULiège > Endocrinologie clinique
Language :
English
Title :
Diagnostic performance of the thirty-four hour dexamethasone suppression test
Publication date :
1985
Journal title :
Psychoneuroendocrinology
ISSN :
0306-4530
eISSN :
1873-3360
Publisher :
Elsevier, United Kingdom
Volume :
10
Pages :
215-219
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 September 2009

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