[en] In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through these interactions, psychological and neurological influences can modulate the immune response (neuroimmunomodulation), while immune cells may communicate to the neuroendocrine system by a regulatory feedback loop. On the basis of our own observations, it has been shown that the neuroendocrine-immune dialogue occurs in the thymus during the early steps of T-cell differentiation, and could be involved both in T-cell positive as well as negative selections.
Defresne, Marie-Paule ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ; Université de Liège - ULiège > Anatomie pathologique
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Lefebvre, Pierre ; Université de Liège - ULiège > Diabétologie,nutrition, maladies métaboliques
Franchimont, Paul
Language :
English
Title :
Neuroendocrine-Immunology: from systemic interactions to the immune tolerance of self neuroendocrine functions
Publication date :
1991
Journal title :
Acta Clinica Belgica
ISSN :
0001-5512
Publisher :
Acta Clinica Belgica, Bruxelles, Belgium
Volume :
46
Pages :
135-141
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] ESF - European Science Foundation [FR] INSERM - Institut National de la Santé et de la Recherche Médicale [FR]