Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area.

Attention/physiology; Brain Mapping; Circadian Rhythm; Cognition/physiology; Female; Homeostasis/physiology; Humans; Magnetic Resonance Imaging; Male; Melatonin/metabolism; Polysomnography; Psychomotor Performance; Sleep/physiology; Suprachiasmatic Nucleus/physiology; Thalamus/physiology; Wakefulness; Young Adult

Abstract :

[en] Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.

Disciplines :

Neurosciences & behavior

Author, co-author :

Schmidt, Christina ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie

Collette, Fabienne ; Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cognitives > Neuropsychologie - Département des sciences cognitives

Leclercq, Yves ; Université de Liège - ULiège > Centre de recherches du cyclotron

Sterpenich, Virginie ; Université de Liège - ULiège > Centre de recherches du cyclotron

Vandewalle, Gilles ; Université de Liège - ULiège > Centre de recherches du cyclotron

Berthomier, Pierre

Berthomier, Christian

Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore)

Tinguely, Gilberte

Darsaud, Annabelle

More authors (11 more)

Language :

English

Title :

Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area.

Publication date :

2009

Journal title :

Science

ISSN :

0036-8075

eISSN :

1095-9203

Publisher :

American Association for the Advancement of Science, Washington, United States - District of Columbia

Volume :

324

Issue :

5926

Pages :

516-9

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 24 September 2009

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123

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144

Bibliography

S. Daan, D. G. M. Beersma, A. A. Borbély, Am. J. Physiol. 246, R161 (1984).
D. J. Dijk, J. F. Duffy, C. A. Czeisler, J. Sleep Res. 1, 112 (1992).
D. M. Edgar, W. C. Dement, C. A. Fuller, J. Neurosci. 13, 1065 (1993).
J. A. Horne, C. G. Brass, A. N. Pettitt, Ergonomics 23, 29 (1980).
G. A. Kerkhof, H. P. Van Dongen, Neurosci. Lett. 218, 153 (1996).
J. F. Duffy, D. J. Dijk, E. F. Hall, C. A. Czeisler, J. Investig. Med. 47, 141 (1999).
E. K. Baehr, W. Revelle, C. I. Eastman, J. Sleep Res. 9, 117 (2000).
V. Mongrain, S. Lavoie, B. Selmaoui, J. Paquet, M. Dumont, J. Biol. Rhythms 19, 248 (2004).
J. Taillard, P. Philip, O. Coste, P. Sagaspe, B. Bioulac, J. Sleep Res. 12, 275 (2003).
G. A. Kerkkof, Electroencephalogr. Clin. Neurophysiol. 78, 197 (1991).
V. Mongrain, J. Carrier, M. Dumont, Eur. J. Neurosci. 23, 497 (2006).
J. K. Wyatt, A. Ritz-De Cecco, C. A. Czeisler, D. J. Dijk, Am. J. Physiol. Regul. Integr. Comp. Physiol. 277, R1152 (1999).
C. Cajochen, S. B. Khalsa, J. K. Wyatt, C. A. Czeisler, D. J. Dijk, Am. J. Physiol. 277, R640 (1999).
D. F. Dinges, J. W. Powell, Behav. Res. Methods Instrum. Comput. 17, 625 (1985).
S. P. Drummond et al., Sleep 28, 1059 (2005).
Supplementary methods and results are available as supporting material on Science Online.
J. Lim, D. F. Dinges, Ann. N. Y. Acad. Sci. 1129, 305 (2008).
J. A. Horne, O. Östberg, Int. J. Chronobiol. 4, 97 (1976).
T. Akerstedt, M. Gillberg, Int. J. Neurosci. 52, 29 (1990).
J. F. Duffy, D. W. Rimmer, C. A. Czeisler, Behav. Neurosci. 115, 895 (2001).
C. Gronfier, K. P. Wright Jr., R. E. Kronauer, C. A. Czeisler, Proc. Natl. Acad. Sci. U.S.A. 104, 9081 (2007).
P. Graw, K. Krauchi, V. Knoblauch, A. Wirz-Justice, C. Cajochen, Physiol. Behav. 80, 695 (2004).
C. M. Portas et al., J. Neurosci. 18, 8979 (1998).
D. Tomasi et al., Cereb. Cortex 19, 233 (2009).
G. Aston-Jones, S. Chen, Y. Zhu, M. L. Oshinsky, Nat. Neurosci. 4, 732 (2001).
D. J. Dijk, D. G. Beersma, S. Daan, J. Biol. Rhythms 2, 207 (1987).
L. A. Finelli, H. Baumann, A. A. Borbely, P. Achermann, Neuroscience 101, 523 (2000).
C. Cajochen, R. Foy, D. J. Dijk, Sleep Res. Online 2, 65 (1999).
T. Deboer, L. Detari, J. H. Meijer, Sleep 30, 257 (2007).
This study was supported by the Belgian Fonds National de la Recherche Scientifique (FNRS), the Fondation Médicale Reine Elisabeth, and the University of Liège. C.S., F.C., Y.L., V.S., G.V., C.P., G.T., A.D., M.D., T.T.D.V., E.S., E.B., and P.M. were supported by the FNRS. M.S. was supported by and Austrian Science Fund Erwin-Schrödinger Fellowship J2470-B02. C.S. was supported by the LUNDBECK-BCNBP grant, P.B. and C.B. are cofounders, employees, and shareholders of PHYSIP company, which setup Aseega software, C.C. was supported by grants from the Swiss National Science Foundation and the Daimler-Benz Foundation. P.P. was supported until 2006 by the Pôle d'Attraction Interuniversitaire (PAI/P504).