Reference : Almotriptan and its combination with aceclofenac for migraine attacks: a study of effica...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/23525
Almotriptan and its combination with aceclofenac for migraine attacks: a study of efficacy and the influence of auto-evaluated brush allodynia.
English
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
De Klippel, N. [> > > >]
Giurgea, S. [> > > >]
Herroelen, L. [> > > >]
Jacquy, J. [> > > >]
Louis, P. [> >]
Monseu, G. [> > > >]
Vandenheede, M. [> >]
2008
Cephalalgia : An International Journal of Headache
Blackwell Science
28
10
1095-105
Yes (verified by ORBi)
International
0333-1024
1468-2982
Osney Mead Oxford
United Kingdom
[en] Adult ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Diclofenac/administration & dosage/analogs & derivatives ; Drug Therapy, Combination ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Migraine Disorders/complications/drug therapy/epidemiology ; Multivariate Analysis ; Physical Stimulation ; Pilot Projects ; Prevalence ; Serotonin Agonists/administration & dosage ; Somatosensory Disorders/drug therapy/epidemiology/etiology ; Treatment Outcome ; Tryptamines/administration & dosage
[en] Early treatment and combining a triptan with a non-steroidal anti-inflammatory drug (NSAID) are thought to improve outcome during migraine attacks, possibly by counteracting the negative influence of cutaneous allodynia. The aim of this multicentre, double-blind pilot study was to evaluate the prevalence of brush allodynia and its relative influence on the efficacy of a triptan-NSAID combination compared with headache intensity at the time of treatment. In a randomized, cross-over design, 112 migraineurs treated two moderate or severe attacks with almotriptan 12.5 mg combined with either aceclofenac 100 mg or placebo. Patients used a 2-cm brush to assess cutaneous allodynia. Allodynia was reported in 34.4% of attacks. The almotriptan-aceclofenac combination was numerically superior to triptan-placebo on 2-24-h sustained pain-free (P = 0.07), 2-h pain-free (P = 0.07) and headache recurrence (P = 0.05) rates, but not on 1-h headache relief. Allodynia numerically reduced treatment success overall, but this effect was not significant for the primary outcome measures. Headache intensity had a significant negative influence on 1-h relief in both attacks (P = 0.0001 and 0.0008, chi(2)) and on 2-24-h sustained pain-free rates in triptan-placebo-treated attacks (P = 0.013). Multivariate logistic regression analysis confirmed that headache intensity at treatment intake, rather than allodynia, significantly influenced most outcome measures, predominantly so in attacks treated with almotriptan and aceclofenac. In the latter, severe compared with moderate headache intensity reduced the likelihood of achieving the primary efficacy end-points [odds ratios (OR) 0.12 and 0.33], whereas allodynia was not a significant explanatory variable (OR 0.76 and 0.65). The results apply to the protocol used here and need to be confirmed in larger studies using quantitative sensory testing.
http://hdl.handle.net/2268/23525
10.1111/j.1468-2982.2008.01654.x

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Almotriptan Schoenen et al 08.pdfPublisher postprint240.91 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.